Desmethylsertraline
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| Systematic (IUPAC) name | |
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(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine
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| Pharmacokinetic data | |
| Biological half-life | 66 hours |
| Excretion | urine |
| Identifiers | |
| CAS Number | 87857-41-8 |
| ATC code | None |
| PubChem | CID: 114743 |
| ChemSpider | 102729 |
| Chemical data | |
| Formula | C16H15Cl2N |
| Molecular mass | 292.20 g/mol |
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Desmethylsertraline (DMS) is an active metabolite of the antidepressant drug sertraline. Like sertraline, desmethylsertraline acts as a monoamine reuptake inhibitor, and may be responsible for some of its parent's therapeutic benefits. However, DMS is significantly less potent relative to sertraline as a serotonin reuptake inhibitor (Ki = 76 nM vs. 3 nM, respectively), but conversely, is more balanced as a monoamine reuptake inhibitor (5-HT (Ki) = 76 nM; NE (Ki) = 420 nM; DA (Ki) = 440 nM), which has the effective result of DMS contrarily behaving as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with about 5.5-fold preference for inhibiting serotonin reuptake relative to catecholamine reuptake.[1]
See also[edit]
References[edit]
- ^ Wong DT, Bymaster FP, Engleman EA (1995). "Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication". Life Sci. 57 (5): 411–41. doi:10.1016/0024-3205(95)00209-o. PMID 7623609.
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