GW0742
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(Redirected from GW-0742)
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| Systematic (IUPAC) name | |
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[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid[1]
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| Identifiers | |
| CAS Number | 317318-84-6 |
| ATC code | None |
| PubChem | CID: 9934458 |
| IUPHAR/BPS | 2686 |
| ChemSpider | 8110086 |
| ChEBI | CHEBI:156132 |
| ChEMBL | CHEMBL38508 |
| Chemical data | |
| Formula | C21H17F4NO3S2 |
| Molecular mass | 471.488 g/mol |
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GW0742 (also known as GW610742) is a PPARδ/β agonist[2][3][4] that is investigated for drug use by GlaxoSmithKline.[citation needed]
See also[edit]
References[edit]
- ^ "Cayman Chemical GW0742". Retrieved 31 Mar 2013.
- ^ Smith, S. A.; Monteith, G. R.; Robinson, J. A.; Venkata, N. G.; May, F. J.; Roberts-Thomson, S. J. (2004). "Effect of the peroxisome proliferator-activated receptor ? Activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research 77 (2): 240–249. doi:10.1002/jnr.20153. PMID 15211590.
- ^ Haskova, Z.; Hoang, B.; Luo, G.; Morgan, L. A.; Billin, A. N.; Barone, F. C.; Shearer, B. G.; Barton, M. E.; Kilgore, K. S. (2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742". Inflammation Research 57 (7): 314–321. doi:10.1007/s00011-007-7157-4. PMID 18622687.
- ^ Sznaidman, M. L.; Haffner, C. D.; Maloney, P. R.; Fivush, A.; Chao, E.; Goreham, D.; Sierra, M. L.; Legrumelec, C.; Xu, H. E.; Montana, V. G.; Lambert, M. H.; Willson, T. M.; Oliver, W. R.; Sternbach, D. D. (2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters 13 (9): 1517. doi:10.1016/S0960-894X(03)00207-5.
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