Class C GPCR
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| 7 transmembrane receptor (metabotropic glutamate family) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | 7tm_3 | ||||||
| Pfam | PF00003 | ||||||
| InterPro | IPR000337 | ||||||
| PROSITE | PDOC00754 | ||||||
| TCDB | 9.A.14 | ||||||
| OPM superfamily | 6 | ||||||
| OPM protein | 4or2 | ||||||
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The class C G-protein-coupled receptors (IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (IPR000162) and several additional receptors.[1]
Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length PubMed. This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors
Contents
Subfamilies[edit]
[edit]
- extracellular calcium-sensing receptor-related IPR000068
GABAB receptors[edit]
- GABAB receptor (gamma-aminobutyric acid) IPR002455
Metabotropic glutamate receptors[edit]
RAIG[edit]
Taste receptors[edit]
Orphan[edit]
Other[edit]
- Bride of sevenless protein IPR002956
- Vomeronasal receptor, type 2 IPR004073
References[edit]
- ^ Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.
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