SLC7A8

Solute carrier family 7 (amino acid transporter light chain, L system), member 8
Identifiers
Symbols	SLC7A8 ; LAT2; LPI-PC1
External IDs	OMIM: 604235 MGI: 1355323 HomoloGene: 8166 IUPHAR: 897 ChEMBL: 4301 GeneCards: SLC7A8 Gene
Gene ontology Molecular function • protein binding • organic cation transmembrane transporter activity • amino acid transmembrane transporter activity • neutral amino acid transmembrane transporter activity • L-amino acid transmembrane transporter activity • toxin transporter activity • peptide antigen binding Cellular component • cytoplasm • plasma membrane • integral component of plasma membrane • basolateral plasma membrane • extracellular vesicular exosome Biological process • cellular amino acid metabolic process • transport • ion transport • amino acid transport • blood coagulation • response to toxic substance • organic cation transport • neutral amino acid transport • leukocyte migration • metal ion homeostasis • transmembrane transport • toxin transport • L-alpha-amino acid transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23428	50934
Ensembl	ENSG00000092068	ENSMUSG00000022180
UniProt	Q9UHI5	Q9QXW9
RefSeq (mRNA)	NM_001267036	NM_016972
RefSeq (protein)	NP_001253965	NP_058668
Location (UCSC)	Chr 14: 23.13 – 23.18 Mb	Chr 14: 54.72 – 54.78 Mb
PubMed search	[1]	[2]

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.

See also

• Heterodimeric amino acid transporter
• Solute carrier family

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  CS1 maint: Explicit use of et al. (link)
• Rossier G, Meier C, Bauch C et al. (2000). "LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine". J. Biol. Chem. 274 (49): 34948–54. doi:10.1074/jbc.274.49.34948. PMID 10574970.  CS1 maint: Explicit use of et al. (link)
• Bassi MT, Sperandeo MP, Incerti B et al. (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family". Genomics 62 (2): 297–303. doi:10.1006/geno.1999.5978. PMID 10610726.  CS1 maint: Explicit use of et al. (link)
• Bröer A, Friedrich B, Wagner CA et al. (2001). "Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains". Biochem. J. 355 (Pt 3): 725–31. PMC 1221788. PMID 11311135.  CS1 maint: Explicit use of et al. (link)
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  CS1 maint: Explicit use of et al. (link)
• Liu X, Charrier L, Gewirtz A et al. (2003). "CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia". J. Biol. Chem. 278 (26): 23672–7. doi:10.1074/jbc.M302777200. PMID 12716892.  CS1 maint: Explicit use of et al. (link)
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  CS1 maint: Explicit use of et al. (link)
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  CS1 maint: Explicit use of et al. (link)
• Li S, Whorton AR (2005). "Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols". J. Biol. Chem. 280 (20): 20102–10. doi:10.1074/jbc.M413164200. PMID 15769744. 
• Kühne A, Kaiser R, Schirmer M et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306.  CS1 maint: Explicit use of et al. (link)