SLCO1A2

Solute carrier organic anion transporter family, member 1A2
Identifiers
Symbols	SLCO1A2 ; OATP; OATP-A; OATP1A2; SLC21A3
External IDs	OMIM: 602883 MGI: 1351896 HomoloGene: 56603 IUPHAR: 1219 ChEMBL: 1743123 GeneCards: SLCO1A2 Gene
Gene ontology Molecular function • organic anion transmembrane transporter activity Cellular component • plasma membrane • integral component of membrane Biological process • bile acid metabolic process • organic anion transport • bile acid and bile salt transport • sodium-independent organic anion transport • small molecule metabolic process • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6579	108096
Ensembl	ENSG00000084453	ENSMUSG00000063975
UniProt	P46721	Q91YY5
RefSeq (mRNA)	NM_005075	NM_001267707
RefSeq (protein)	NP_066580	NP_001254636
Location (UCSC)	Chr 12: 21.42 – 21.57 Mb	Chr 6: 142.23 – 142.32 Mb
PubMed search	[1]	[2]

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.

See also

• Solute carrier family

Further reading

• Meier PJ, Eckhardt U, Schroeder A et al. (1998). "Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver". Hepatology 26 (6): 1667–77. doi:10.1002/hep.510260641. PMID 9398014.  CS1 maint: Explicit use of et al. (link)
• Kullak-Ublick GA, Hagenbuch B, Stieger B et al. (1995). "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver". Gastroenterology 109 (4): 1274–82. doi:10.1016/0016-5085(95)90588-X. PMID 7557095.  CS1 maint: Explicit use of et al. (link)
• Kullak-Ublick GA, Beuers U, Fahney C et al. (1997). "Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene". Hepatology 26 (4): 991–7. doi:10.1002/hep.510260429. PMID 9328325.  CS1 maint: Explicit use of et al. (link)
• Kullak-Ublick GA, Fisch T, Oswald M et al. (1998). "Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain". FEBS Lett. 424 (3): 173–6. doi:10.1016/S0014-5793(98)00168-9. PMID 9539145.  CS1 maint: Explicit use of et al. (link)
• König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507. 
• Tamai I, Nezu J, Uchino H et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.  CS1 maint: Explicit use of et al. (link)
• Speek M (2001). "Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  CS1 maint: Explicit use of et al. (link)
• Lee W, Glaeser H, Smith LH et al. (2005). "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry". J. Biol. Chem. 280 (10): 9610–7. doi:10.1074/jbc.M411092200. PMID 15632119.  CS1 maint: Explicit use of et al. (link)
• Su Y, Zhang X, Sinko PJ (2005). "Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells". Mol. Pharm. 1 (1): 49–56. doi:10.1021/mp0340136. PMID 15832500. 
• Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.  CS1 maint: Explicit use of et al. (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.