ARID4A
From Wikipedia, the free encyclopedia
| AT rich interactive domain 4A (RBP1-like) | ||||||||
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| Identifiers | ||||||||
| Symbols | ARID4A; RBBP-1; RBBP1; RBP-1; RBP1 | |||||||
| External IDs | OMIM: 180201 MGI: 2444354 HomoloGene: 11303 GeneCards: ARID4A Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 5926 | 238247 | ||||||
| Ensembl | ENSG00000032219 | ENSMUSG00000048118 | ||||||
| UniProt | P29374 | E9Q9V1 | ||||||
| RefSeq (mRNA) | NM_002892 | NM_001081195 | ||||||
| RefSeq (protein) | NP_002883 | NP_001074664 | ||||||
| Location (UCSC) | Chr 14: 58.77 – 58.84 Mb |
Chr 12: 71.02 – 71.1 Mb |
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| PubMed search | [1] | [2] | ||||||
AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.[1][2][3]
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Function[edit]
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.[1]
Model organisms[edit]
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Abnormal |
| Recessive lethal study | Abnormal |
| Fertility | Normal |
| Body weight | Abnormal[4] |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Abnormal[5] |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Abnormal[6] |
| Radiography | Abnormal[7] |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Abnormal[8] |
| Haematology | Abnormal[9] |
| Peripheral blood lymphocytes | Abnormal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Skin Histopathology | Normal |
| Eye Histopathology | Normal |
| Salmonella infection | Normal[10] |
| Citrobacter infection | Normal[11] |
| All tests and analysis from[12][13] |
Model organisms have been used in the study of ARID4A function. A conditional knockout mouse line, called Arid4atm1a(EUCOMM)Wtsi[14][15] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[16][17][18] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[12][19]
Twenty five tests were carried out and nine phenotypes were reported. Fewer homozygous mutant embryos were identified during gestation than expected, and in a separate study less than the predicted Mendelian ratio survived until weaning. Homozygous mutant male adults has a reduced body weight curve and a decreased grip strength. Homozygous mutant adults of both sexes had a decreased body weight as determined by DEXA, displayed vertebral fusion and had clinical chemistry abnormalities including hypoalbuminemia and decreased circulating fructosamine levels. They also had haematological defects and an increased NK cell number.[12]
Interactions[edit]
ARID4A has been shown to interact with Retinoblastoma protein.[20]
References[edit]
- ^ a b "Entrez Gene: ARID4A AT rich interactive domain 4A (RBP1-like)".
- ^ Defeo-Jones D, Huang PS, Jones RE, Haskell KM, Vuocolo GA, Hanobik MG, Huber HE, Oliff A (July 1991). "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product". Nature 352 (6332): 251–4. doi:10.1038/352251a0. PMID 1857421.
- ^ Otterson GA, Kratzke RA, Lin AY, Johnston PG, Kaye FJ (April 1993). "Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites". Oncogene 8 (4): 949–57. PMID 8455946.
- ^ "Body weight data for Arid4a". Wellcome Trust Sanger Institute.
- ^ "Grip strength data for Arid4a". Wellcome Trust Sanger Institute.
- ^ "DEXA data for Arid4a". Wellcome Trust Sanger Institute.
- ^ "Radiography data for Arid4a". Wellcome Trust Sanger Institute.
- ^ "Clinical chemistry data for Arid4a". Wellcome Trust Sanger Institute.
- ^ "Haematology data for Arid4a". Wellcome Trust Sanger Institute.
- ^ "Salmonella infection data for Arid4a". Wellcome Trust Sanger Institute.
- ^ "Citrobacter infection data for Arid4a". Wellcome Trust Sanger Institute.
- ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
- ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
- ^ "International Knockout Mouse Consortium".
- ^ "Mouse Genome Informatics".
- ^ Skarnes Wc, R. B.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M. et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMID 21677750.
- ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
- ^ Lai, A; Lee J M, Yang W M, DeCaprio J A, Kaelin W G, Seto E, Branton P E (Oct. 1999). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 6632–41. ISSN 0270-7306. PMC 84642. PMID 10490602.
Further reading[edit]
- Defeo-Jones D, Huang PS, Jones RE, et al. (1991). "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product.". Nature 352 (6332): 251–4. doi:10.1038/352251a0. PMID 1857421.
- Fattaey AR, Helin K, Dembski MS, et al. (1993). "Characterization of the retinoblastoma binding proteins RBP1 and RBP2.". Oncogene 8 (11): 3149–56. PMID 8414517.
- Otterson GA, Kratzke RA, Lin AY, et al. (1993). "Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites.". Oncogene 8 (4): 949–57. PMID 8455946.
- Margottin F, Bour SP, Durand H, et al. (1998). "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.". Mol. Cell 1 (4): 565–74. doi:10.1016/S1097-2765(00)80056-8. PMID 9660940.
- Lai A, Marcellus RC, Corbeil HB, Branton PE (1999). "RBP1 induces growth arrest by repression of E2F-dependent transcription.". Oncogene 18 (12): 2091–100. doi:10.1038/sj.onc.1202520. PMID 10321733.
- Cao J, Gao T, Giuliano AE, Irie RF (1999). "Recognition of an epitope of a breast cancer antigen by human antibody.". Breast Cancer Res. Treat. 53 (3): 279–90. doi:10.1023/A:1006115922401. PMID 10369074.
- Lai A, Lee JM, Yang WM, et al. (2000). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins.". Mol. Cell. Biol. 19 (10): 6632–41. PMC 84642. PMID 10490602.
- Lai A, Kennedy BK, Barbie DA, et al. (2001). "RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.". Mol. Cell. Biol. 21 (8): 2918–32. doi:10.1128/MCB.21.8.2918-2932.2001. PMC 86920. PMID 11283269.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex.". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
- Meehan WJ, Samant RS, Hopper JE, et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.". J. Biol. Chem. 279 (2): 1562–9. doi:10.1074/jbc.M307969200. PMID 14581478.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Monroe DG, Secreto FJ, Hawse JR, et al. (2006). "Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements.". J. Biol. Chem. 281 (39): 28596–604. doi:10.1074/jbc.M605226200. PMID 16873370.
External links[edit]
- ARID4A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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