GPRC5C

G protein-coupled receptor, family C, group 5, member C
Identifiers
Symbols	GPRC5C; RAIG-3; RAIG3
External IDs	OMIM: 605949 MGI: 1917605 HomoloGene: 11099 IUPHAR: GPRC5C GeneCards: GPRC5C Gene
Gene Ontology Molecular function • G-protein coupled receptor activity Cellular component • mitochondrion • integral to plasma membrane • cytoplasmic vesicle membrane Biological process • G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55890	70355
Ensembl	ENSG00000170412	ENSMUSG00000051043
UniProt	Q9NQ84	Q8K3J9
RefSeq (mRNA)	NM_018653	NM_001110337
RefSeq (protein)	NP_061123	NP_001103807
Location (UCSC)	Chr 17: 72.42 – 72.45 Mb	Chr 11: 114.85 – 114.87 Mb
PubMed search	[1]	[2]

G-protein coupled receptor family C group 5 member C is a protein that in humans is encoded by the GPRC5C gene.

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene.

See also

• Retinoic acid-inducible orphan G protein-coupled receptor

External links

• "GPRC5 Receptors: RAIG₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259. 
• Bräuner-Osborne H, Jensen AA, Sheppard PO, (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta 1518 (3): 237–48. PMID 11311935. 
• Strausberg RL, Feingold EA, Grouse LH, (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Lehner B, Semple JI, Brown SE, (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
• Ota T, Suzuki Y, Nishikawa T, (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rual JF, Venkatesan K, Hao T, (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Otsuki T, Ota T, Nishikawa T, (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.