Thioperamide

Thioperamide

Systematic (IUPAC) name
N-Cyclohexyl-4-(1H-imidazol-4-yl)piperidine-1-carbothioamide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	106243-16-7 Y
ATC code	None
PubChem	CID 3035905
IUPHAR ligand	1267
ChemSpider	2300031 Y
ChEMBL	CHEMBL260374 Y
Chemical data
Formula	C15H24N4S
Mol. mass	292.44 g/mol
SMILES S=C(N2CCC(c1cncn1)CC2)NC3CCCCC3
InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) Y Key:QKDDJDBFONZGBW-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Thioperamide is a potent and selective histamine H₃ antagonist that is capable of crossing the blood–brain barrier. Thioperamide was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.[1] Thioperamide was found to be an antagonist of histamine autoreceptors, which detect the presence of histamine. Thioperamide enhances the activity of histaminergic neurons by blocking autoreceptors, thus preventing the detection of histamine by neurons. This causes the neurons to release more histamine, thus increasing their activity.

See also

• H₃ receptor antagonist