Mosapride

Mosapride
Systematic (IUPAC) name
	(RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	112885-41-3
ATC code	None
PubChem	CID 119584
IUPHAR ligand	242
ChemSpider	106780
UNII	I8MFJ1C0BY
KEGG	D08236
ChEMBL	CHEMBL60889
Chemical data
Formula	C21H25ClFN3O3
Mol. mass	421.893 g/mol
	SMILES Clc1cc(c(OCC)cc1N)C(=O)NCC3OCCN(Cc2ccc(F)cc2)C3;
	InChI InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27) ; Key:YPELFRMCRYSPKZ-UHFFFAOYSA-N ;
(what is this?) (verify);

Mosapride is a gastroprokinetic agent that acts as a selective 5HT₄ agonist^[1] which accelerates gastric emptying and is used for the treatment of acid reflux,^[2] irritable bowel syndrome and functional dyspepsia.^[3] Its common side effects include diarrhea, abdominal pain, dizziness, constipation, headache, insomnia, and nausea.^[4]

References [edit]

^ Kato S, Morie T, Yoshida N. Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent. Chemical and Pharmaceutical Bulletin (Tokyo). 1995 Apr;43(4):699-702.
^ Ruth M, Hamelin B, Rohss K, Lundell L. The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics. 1998 Jan;12(1):35-40.
^ Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, Omagari K, Takeshima F, Kohno S. Recent insights into digestive motility in functional dyspepsia. Journal of Gastroenterology. 2006 Nov;41(11):1025-40.
^ Mosapride drug information - Drugs Update India

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.