Cirazoline
| Cirazoline | |
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2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole |
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| Identifiers | |
| CAS number | 59939-16-1 |
| PubChem | 2765 |
| ChemSpider | 2663  |
| MeSH | cirazoline |
| ChEMBL | CHEMBL13852 |
| IUPHAR ligand | 515 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C13H16N2O |
| Molar mass | 216.279 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references |
Cirazoline is a nonselective agonist of the alpha-1 adrenergic receptor (α1-AR), and an antagonist to the alpha-2 adrenergic receptor.[1] It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.[1]
Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.[2]
References [edit]
- ^ a b Ruffolo, R. R. Jr.; Waddell, J. E. (1982). "Receptor interactions of imidazolines. IX. Cirazoline is an α1 adrenergic agonist and an α2 adrenergic antagonist". Journal of Pharmacology and Experimental Therapeutics 222 (1): 29–36. PMID 6123592.
- ^ Davies, B. T.; Wellman, P. J. (1992). "Effects on ingestive behavior in rats of the α1-adrenoceptor agonist cirazoline". European Journal of Pharmacology 210 (1): 11–16. doi:10.1016/0014-2999(92)90645-K. PMID 1350985.
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