Fenmetozole (DH-524) is a drug which was patented as an antidepressant,[1][2] but was later studied as an antagonist of the effects of ethanol, though results were poor and it even increased its effects in some cases.[3][4][5][6][7] It acts as an α2-adrenergic receptor antagonist similarly to other imidazoles like idazoxan.[8] It was never marketed.[2]
References [edit]
- ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
- ^ a b David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
- ^ McNamee HB, Mendelson JH, Korn J (June 1975). "Fenmetozole in acute alcholol intoxication in man". Clinical Pharmacology and Therapeutics 17 (6): 735–7. PMID 1095283.
- ^ Griffis LC, Bright TP, Cerimele BJ, Forney RB (September 1978). "Combined effects of fenmetozole and ethanol". Clinical Pharmacology and Therapeutics 24 (3): 350–3. PMID 357069.
- ^ Frye GD, Breese GR, Mailman RB, Vogel RA, Ondrusek MG, Mueller RA (1980). "An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function". Psychopharmacology 69 (2): 149–55. doi:10.1007/BF00427641. PMID 6256788.
- ^ Vogel RA, Frye GD, Koepke KM, Mailman RB, Mueller RA, Breese GR (1981). "Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex". Alcoholism, Clinical and Experimental Research 5 (3): 386–92. PMID 6792942.
- ^ Frye GD, Breese GR (1981). "An evaluation of the locomotor stimulating action of ethanol in rats and mice". Psychopharmacology 75 (4): 372–9. doi:10.1007/BF00435856. PMID 6803283.
- ^ Stillings MR, England CD, Welbourn AP, Smith CF (September 1986). "Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists". Journal of Medicinal Chemistry 29 (9): 1780–3. doi:10.1021/jm00159a037. PMID 2875186.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Serotonin modulators and stimulators (SMSs)
|
|
|
|
Others
|
|
|
|
|
|
|
|
|
|
|
|
Nonselective
|
|
|
|
MAOA-Selective
|
|
|
|
MAOB-Selective
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
* Note that MAO-B inhibitors also influence norepinephrine/epinephrine levels since they inhibit the breakdown of their precursor dopamine.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
