KLF9
From Wikipedia, the free encyclopedia
| Kruppel-like factor 9 | ||||||||
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| Identifiers | ||||||||
| Symbols | KLF9; BTEB; BTEB1 | |||||||
| External IDs | OMIM: 602902 MGI: 1333856 HomoloGene: 931 GeneCards: KLF9 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 687 | 16601 | ||||||
| Ensembl | ENSG00000119138 | ENSMUSG00000033863 | ||||||
| UniProt | Q13886 | O35739 | ||||||
| RefSeq (mRNA) | NM_001206 | NM_010638 | ||||||
| RefSeq (protein) | NP_001197 | NP_034768 | ||||||
| Location (UCSC) | Chr 9: 73 – 73.03 Mb |
Chr 19: 23.14 – 23.17 Mb |
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| PubMed search | [1] | [2] | ||||||
Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene.[1][2]
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription.[2]
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[edit] Interactions
KLF9 has been shown to interact with Progesterone receptor.[3]
[edit] References
- ^ Imataka H, Sogawa K, Yasumoto K, Kikuchi Y, Sasano K, Kobayashi A, Hayami M, Fujii-Kuriyama Y (Nov 1992). "Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene". EMBO J 11 (10): 3663–71. PMC 556826. PMID 1356762.
- ^ a b "Entrez Gene: KLF9 Kruppel-like factor 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=687.
- ^ Zhang, Xue-Lian; Zhang Daying, Michel Frank J, Blum Jason L, Simmen Frank A, Simmen Rosalia C M (Jun. 2003). "Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells". J. Biol. Chem. (United States) 278 (24): 21474–82. doi:10.1074/jbc.M212098200. ISSN 0021-9258. PMID 12672823.
[edit] Further reading
- Kobayashi A, Sogawa K, Imataka H, Fujii-Kuriyama Y (1995). "Analysis of functional domains of a GC box-binding protein, BTEB". J. Biochem. 117 (1): 91–5. PMID 7775404.
- Imataka H, Nakayama K, Yasumoto K et al. (1994). "Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region". J. Biol. Chem. 269 (32): 20668–73. PMID 8051167.
- Imataka H, Mizuno A, Fujii-Kuriyama Y, Hayami M (1994). "Activation of the human immunodeficiency virus type 1 long terminal repeat by BTEB, a GC box-binding transcription factor". AIDS Res. Hum. Retroviruses 9 (9): 825–31. doi:10.1089/aid.1993.9.825. PMID 8257632.
- Hashimoto H, Toide K, Kitamura R et al. (1994). "Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control". Eur. J. Biochem. 218 (2): 585–95. doi:10.1111/j.1432-1033.1993.tb18412.x. PMID 8269949.
- Ohe N, Yamasaki Y, Sogawa K et al. (1994). "Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein". Somat. Cell Mol. Genet. 19 (5): 499–503. doi:10.1007/BF01233255. PMID 8291025.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang XL, Zhang D, Michel FJ et al. (2003). "Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells". J. Biol. Chem. 278 (24): 21474–82. doi:10.1074/jbc.M212098200. PMID 12672823.
- Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Velarde MC, Iruthayanathan M, Eason RR et al. (2006). "Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1". Endocrinology 147 (4): 1969–78. doi:10.1210/en.2005-1419. PMID 16384861.
[edit] External links
- KLF9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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