JunD

Jun D proto-oncogene
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3U86
Identifiers
Symbols	JUND; AP-1
External IDs	OMIM: 165162 MGI: 96648 HomoloGene: 3910 GeneCards: JUND Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding • transcription regulatory region DNA binding Cellular component • chromatin • nucleus Biological process • osteoblast development • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • positive regulation of osteoblast differentiation • positive regulation of transcription from RNA polymerase II promoter • cellular response to calcium ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3727	16478
Ensembl	ENSG00000130522	ENSMUSG00000071076
UniProt	P17535	P15066
RefSeq (mRNA)	NM_005354	NM_010592
RefSeq (protein)	NP_005345	NP_034722
Location (UCSC)	Chr 19: 18.39 – 18.39 Mb	Chr 8: 70.7 – 70.7 Mb
PubMed search	[1]	[2]

Transcription factor jun-D is a protein that in humans is encoded by the JUND gene.

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.

Interactions

JunD has been shown to interact with ATF3, MEN1, DNA damage-inducible transcript 3 and BRCA1.

See also

• AP-1 (transcription factor)

Further reading

• Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.". Biochem. J. 273(Pt 2): 477–9. PMC 1149869. PMID 1899335. 
• Franklin CC, McCulloch AV, Kraft AS (1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.". Biochem. J. 305 (3): 967–74. PMC 1136352. PMID 7848298. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Chu HM, Tan Y, Kobierski LA, et al. (1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression.". Mol. Endocrinol. 8 (1): 59–68. doi:10.1210/me.8.1.59. PMID 8152431. 
• Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525. 
• Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175. 
• Claret FX, Hibi M, Dhut S, et al. (1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.". Nature 383 (6599): 453–7. doi:10.1038/383453a0. PMID 8837781. 
• Kallunki T, Deng T, Hibi M, Karin M (1997). "c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.". Cell 87 (5): 929–39. doi:10.1016/S0092-8674(00)81999-6. PMID 8945519. 
• Aronheim A, Zandi E, Hennemann H, et al. (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.". Mol. Cell. Biol. 17 (6): 3094–102. PMC 232162. PMID 9154808. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Labudova O, Krapfenbauer K, Moenkemann H, et al. (1998). "Decreased transcription factor junD in brains of patients with Down syndrome.". Neurosci. Lett. 252 (3): 159–62. doi:10.1016/S0304-3940(98)00569-2. PMID 9739985. 
• Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330. 
• Agarwal SK, Guru SC, Heppner C, et al. (1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.". Cell 96 (1): 143–52. doi:10.1016/S0092-8674(00)80967-8. PMID 9989505. 
• Liberati NT, Datto MB, Frederick JP, et al. (1999). "Smads bind directly to the Jun family of AP-1 transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381. 
• Gobl AE, Berg M, Lopez-Egido JR, et al. (1999). "Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism.". Biochim. Biophys. Acta 1447 (1): 51–6. doi:10.1016/S0167-4781(99)00132-3. PMID 10500243. 
• Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.". Mol. Cell. Biol. 19 (11): 7589–99. PMC 84780. PMID 10523647. 
• Miyamoto NG, Medberry PS, Hesselgesser J, et al. (2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors.". J. Neuroimmunol. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367. 
• Sharma SC, Richards JS (2000). "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation.". J. Biol. Chem. 275 (43): 33718–28. doi:10.1074/jbc.M003555200. PMID 10934195. 

External links

• JUND protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook JunD

This article incorporates text from the United States National Library of Medicine, which is in the public domain.