T-box

T-box
	Crystallographic structure of the TBX3 protein dimer (cyan and green) complexed with DNA (brown) based on the PDB 1h6f coordinates.
Identifiers
Symbol	T-box
Pfam	PF00907
InterPro	IPR001699
PROSITE	PS50252
SCOP	1xbr
SUPERFAMILY	1xbr
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

T-box refers to a group of transcription factors involved in limb and heart development.^[1] In humans and some other animals, defects in the TBX5 gene expression can lead to finger-like thumbs and ventricular septal defects in which there is no separation between the left and right ventricle of the heart and are responsible for Holt-Oram syndrome.

Genes encoding T-box proteins include:

[edit] See also

T-Box Domain Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

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