MKX

For the automobile, see Lincoln MKX.

Mohawk homeobox
Identifiers
Symbols	MKX; C10orf48; IFRX; IRXL1
External IDs	OMIM: 601332 MGI: 2687286 HomoloGene: 72239 GeneCards: MKX Gene
Gene Ontology Molecular function • sequence-specific DNA binding RNA polymerase II transcription factor activity • RNA polymerase II transcription factor binding • sequence-specific DNA binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • tendon sheath development • muscle organ development • positive regulation of gene expression • collagen fibril organization • positive regulation of collagen biosynthetic process • tendon cell differentiation • negative regulation of myoblast differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	283078	210719
Ensembl	ENSG00000150051	ENSMUSG00000061013
UniProt	Q8IYA7	Q8BIA3
RefSeq (mRNA)	NM_001242702	NM_177595
RefSeq (protein)	NP_001229631	NP_808263
Location (UCSC)	Chr 10: 27.96 – 28.03 Mb	Chr 18: 6.94 – 7 Mb
PubMed search	[1]	[2]

Homeobox protein Mohawk, also known as iroquois homeobox protein-like 1, is a protein that in humans is encoded by the MKX (mohawk homeobox) gene.

Function

MKX is a member of an Iroquois (IRX) family-related class of 'three-amino acid loop extension' (TALE) atypical homeobox proteins characterized by 3 additional amino acids in the loop region between helix I and helix II of the homeodomain.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. 
• Weinmann A, Galle PR, Teufel A (2005). "In silico characterization of an Iroquois family-related homeodomain protein.". Int. J. Mol. Med. 16 (3): 443–8. PMID 16077953. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Anderson DM, Arredondo J, Hahn K, et al. (2006). "Mohawk is a novel homeobox gene expressed in the developing mouse embryo.". Dev. Dyn. 235 (3): 792–801. doi:10.1002/dvdy.20671. PMID 16408284. 
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome.". Mol. Cell Proteomics 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.