NKX3-1

NK3 homeobox 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2L9R
Identifiers
Symbols	NKX3-1; BAPX2; NKX3; NKX3.1; NKX3A
External IDs	OMIM: 602041 MGI: 97352 HomoloGene: 4494 GeneCards: NKX3-1 Gene
Gene Ontology Molecular function • transcription regulatory region sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity • protein binding transcription factor activity • core promoter binding • sequence-specific DNA binding transcription factor activity • androgen receptor activity • protein binding • transcription factor binding • cysteine-type endopeptidase activator activity involved in apoptotic process • estrogen receptor activity • protein kinase activator activity • estrogen receptor binding • histone deacetylase binding • sequence-specific DNA binding • protein self-association • transcription regulatory region DNA binding • MADS box domain binding Cellular component • intracellular • nucleus Biological process • metanephros development • somitogenesis • positive regulation of protein phosphorylation • regulation of transcription, DNA-dependent • activation of cysteine-type endopeptidase activity involved in apoptotic process • multicellular organismal development • salivary gland development • heart development • positive regulation of cell proliferation • negative regulation of cell proliferation • male gonad development • positive regulation of gene expression • negative regulation of gene expression • positive regulation of cell death • positive regulation of phosphatidylinositol 3-kinase cascade • androgen receptor signaling pathway • response to testosterone stimulus • cellular response to drug • dorsal aorta development • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • protein kinase B signaling cascade • negative regulation of insulin-like growth factor receptor signaling pathway • positive regulation of protein kinase activity • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • negative regulation of mitotic cell cycle • positive regulation of mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • branching morphogenesis of a tube • negative regulation of epithelial cell proliferation • positive regulation of cell division • pharyngeal system development • branching involved in prostate gland morphogenesis • epithelial cell proliferation involved in salivary gland morphogenesis • negative regulation of epithelial cell proliferation involved in prostate gland development • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to steroid hormone stimulus • cellular response to hypoxia • mitotic cell cycle arrest • negative regulation of estrogen receptor binding • positive regulation of androgen secretion • positive regulation of response to DNA damage stimulus • positive regulation of apoptotic signaling pathway • positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4824	18095
Ensembl	ENSG00000167034	ENSMUSG00000022061
UniProt	Q99801	P97436
RefSeq (mRNA)	NM_001256339	NM_010921
RefSeq (protein)	NP_001243268	NP_035051
Location (UCSC)	Chr 8: 23.54 – 23.54 Mb	Chr 14: 69.19 – 69.19 Mb
PubMed search	[1]	[2]

Homeobox protein Nkx-3.1 is a protein that in humans is encoded by the NKX3-1 gene.

The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM]

Interactions

NKX3-1 has been shown to interact with SPDEF.

Further reading

• Shen MM, Abate-Shen C (2004). "Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis.". Dev. Dyn. 228 (4): 767–78. doi:10.1002/dvdy.10397. PMID 14648854. 
• Abdulkadir SA (2006). "Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1.". Ann. N. Y. Acad. Sci. 1059: 33–40. doi:10.1196/annals.1339.018. PMID 16382041. 
• Voeller HJ, Augustus M, Madike V, et al. (1997). "Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.". Cancer Res. 57 (20): 4455–9. PMID 9377551. 
• Prescott JL, Blok L, Tindall DJ (1998). "Isolation and androgen regulation of the human homeobox cDNA, NKX3.1.". Prostate 35 (1): 71–80. doi:10.1002/(SICI)1097-0045(19980401)35:1<71::AID-PROS10>3.0.CO;2-H. PMID 9537602. 
• Choi CY, Kim YH, Kwon HJ, Kim Y (1999). "The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription.". J. Biol. Chem. 274 (47): 33194–7. doi:10.1074/jbc.274.47.33194. PMID 10559189. 
• Carson JA, Fillmore RA, Schwartz RJ, Zimmer WE (2001). "The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor.". J. Biol. Chem. 275 (50): 39061–72. doi:10.1074/jbc.M006532200. PMID 10993896. 
• Bowen C, Bubendorf L, Voeller HJ, et al. (2000). "Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.". Cancer Res. 60 (21): 6111–5. PMID 11085535. 
• Korkmaz KS, Korkmaz CG, Ragnhildstveit E, et al. (2001). "Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens.". Gene 260 (1–2): 25–36. doi:10.1016/S0378-1119(00)00453-4. PMID 11137288. 
• Chen H, Nandi AK, Li X, Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. 62 (2): 338–40. PMID 11809674. 
• Filmore RA, Dean DA, Zimmer WE (2003). "The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia". Gene Expr. 10 (5–6): 201–11. PMID 12450213. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Gelmann EP, Bowen C, Bubendorf L (2003). "Expression of NKX3.1 in normal and malignant tissues". Prostate 55 (2): 111–7. doi:10.1002/pros.10210. PMID 12661036. 
• Skotheim RI, Korkmaz KS, Klokk TI, et al. (2004). "NKX3.1 Expression Is Lost in Testicular Germ Cell Tumors". Am. J. Pathol. 163 (6): 2149–54. doi:10.1016/S0002-9440(10)63571-7. PMC 1892359. PMID 14633588. 
• Korkmaz CG, Korkmaz KS, Manola J, et al. (2004). "Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis". J. Urol. 172 (3): 1134–9. doi:10.1097/01.ju.0000136526.78535.b8. PMID 15311057. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Chen H, Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF". J. Cell. Biochem. 94 (1): 168–77. doi:10.1002/jcb.20297. PMID 15523673. 
• Lind GE, Skotheim RI, Fraga MF, et al. (2005). "The loss of NKX3.1 expression in testicular – and prostate – cancers is not caused by promoter hypermethylation". Mol. Cancer 4 (1): 8. doi:10.1186/1476-4598-4-8. PMC 548671. PMID 15691383. 
• Asatiani E, Huang WX, Wang A, et al. (2005). "Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer". Cancer Res. 65 (4): 1164–73. doi:10.1158/0008-5472.CAN-04-2688. PMID 15734999. 

External links

• NKX3-1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.