MLLT1

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
Identifiers
Symbols	MLLT1; ENL; LTG19; YEATS1
External IDs	OMIM: 159556 MGI: 1927238 HomoloGene: 4339 GeneCards: MLLT1 Gene
Gene Ontology Molecular function • DNA binding • protein binding Cellular component • nucleus • nucleolus • cytoplasm Biological process • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • negative regulation of protein kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4298	64144
Ensembl	ENSG00000130382	ENSMUSG00000024212
UniProt	Q03111	Q9ERL0
RefSeq (mRNA)	NM_005934	NM_022328
RefSeq (protein)	NP_005925	NP_071723
Location (UCSC)	Chr 19: 6.21 – 6.28 Mb	Chr 17: 56.89 – 56.94 Mb
PubMed search	[1]	[2]

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.

Interactions

MLLT1 has been shown to interact with CBX8.

Further reading

• Tkachuk DC, Kohler S, Cleary ML (1992). "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias". Cell 71 (4): 691–700. doi:10.1016/0092-8674(92)90602-9. PMID 1423624. 
• Thirman MJ, Levitan DA, Kobayashi H et al. (1995). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12110–12114. doi:10.1073/pnas.91.25.12110. PMC 45386. PMID 7991593. 
• Rubnitz JE, Morrissey J, Savage PA, Cleary ML (1994). "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells". Blood 84 (6): 1747–52. PMID 8080983. 
• Yamamoto K, Seto M, Komatsu H et al. (1993). "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia". Oncogene 8 (10): 2617–25. PMID 8378076. 
• Lavau C, Luo RT, Du C, Thirman MJ (2000). "Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10984–10989. doi:10.1073/pnas.190167297. PMC 27135. PMID 10995463. 
• García-Cuéllar MP, Zilles O, Schreiner SA et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene 20 (4): 411–419. doi:10.1038/sj.onc.1204108. PMID 11313972. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Nie Z, Yan Z, Chen EH et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–2952. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591. 
• Gué M, Sun JS, Boudier T (2006). "Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited". BMC Cancer 6: 20. doi:10.1186/1471-2407-6-20. PMC 1388228. PMID 16433901. 
• Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Meyer C, Burmeister T, Strehl S et al. (2007). "Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia". Leukemia 21 (3): 588–590. doi:10.1038/sj.leu.2404542. PMID 17252016. 

External links

• MLLT1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.