MYCL1

V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
Identifiers
Symbols	MYCL1; LMYC; MYCL; bHLHe38
External IDs	OMIM: 164850 MGI: 96799 HomoloGene: 3921 GeneCards: MYCL1 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • protein dimerization activity Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4610	16918
Ensembl	ENSG00000116990	ENSMUSG00000028654
UniProt	P12524	P10166
RefSeq (mRNA)	NM_001033081	NM_008506
RefSeq (protein)	NP_001028253	NP_032532
Location (UCSC)	Chr 1: 40.36 – 40.37 Mb	Chr 4: 123 – 123 Mb
PubMed search	[1]	[2]

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.

Interactions

MYCL1 has been shown to interact with MAX.

Further reading

• Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene 277 (1–2): 1–14. doi:10.1016/S0378-1119(01)00697-7. PMID 11602341. 
• Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855. 
• Kaye F, Battey J, Nau M et al. (1988). "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing". Mol. Cell. Biol. 8 (1): 186–95. PMC 363100. PMID 2827002. 
• De Greve J, Battey J, Fedorko J et al. (1988). "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs". Mol. Cell. Biol. 8 (10): 4381–8. PMC 365511. PMID 3054516. 
• DePinho RA, Hatton KS, Tesfaye A et al. (1988). "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene". Genes Dev. 1 (10): 1311–1326. doi:10.1101/gad.1.10.1311. PMID 3322939. 
• Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10217–10221. doi:10.1073/pnas.92.22.10217. PMC 40767. PMID 7479755. 
• FitzGerald MJ, Arsura M, Bellas RE et al. (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200. 
• Kumimoto H, Hamajima N, Nishimoto Y et al. (2002). "L-myc genotype is associated with different susceptibility to lung cancer in smokers". Jpn. J. Cancer Res. 93 (1): 1–5. PMID 11802801. 
• Suzuki H, Yamashiro K (2002). "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. Rep. 9 (2): 345–7. PMID 11836605. 
• Primdahl H, von der Maase H, Christensen M et al. (2002). "Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ". Oncol. Rep. 9 (3): 551–5. PMID 11956626. 
• Demopoulos K, Arvanitis DA, Vassilakis DA et al. (2003). "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis". J. Cell. Mol. Med. 6 (2): 215–222. doi:10.1111/j.1582-4934.2002.tb00188.x. PMID 12169206. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Wu R, Lin L, Beer DG et al. (2003). "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603–10. doi:10.1016/S0002-9440(10)64294-0. PMC 1851191. PMID 12707044. 
• Kambara T, Sharp GB, Nagasaka T et al. (2004). "Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer". Clin. Cancer Res. 10 (5): 1758–1763. doi:10.1158/1078-0432.CCR-0779-3. PMID 15014029. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
• Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–321. doi:10.1038/nature04727. PMID 16710414. 
• Spinola M, Falvella FS, Galvan A et al. (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival". Lung Cancer 55 (3): 271–277. doi:10.1016/j.lungcan.2006.10.023. PMID 17145094. 

External links

• MYCL1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.