FOXG1

Forkhead box G1
Identifiers
Symbols	FOXG1; BF1; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; QIN
External IDs	OMIM: 164874 MGI: 1347464 HomoloGene: 3843 GeneCards: FOXG1 Gene
Gene Ontology Molecular function • DNA binding • double-stranded DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • protein binding • transcription factor binding • DNA binding, bending • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • positive regulation of neuroblast proliferation • regulation of transcription, DNA-dependent • regulation of mitotic cell cycle • brain development • embryo development ending in birth or egg hatching • tissue development • dorsal/ventral pattern formation • axon midline choice point recognition • central nervous system neuron development • forebrain development • hindbrain development • nonmotile primary cilium assembly • inner ear morphogenesis • nose development • negative regulation of neuron differentiation • positive regulation of cell cycle • negative regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2290	15228
Ensembl	ENSG00000176165	ENSMUSG00000020950
UniProt	P55316	Q60987
RefSeq (mRNA)	NM_005249	NM_001160112
RefSeq (protein)	NP_005240	NP_001153584
Location (UCSC)	Chr 14: 29.24 – 29.24 Mb	Chr 12: 49.38 – 49.39 Mb
PubMed search	[1]	[2]

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon.

See also

• FOX proteins

Interactions

FOXG1 has been shown to interact with JARID1B.

Further reading

• Li J, Chang HW, Lai E, et al. (1995). "The oncogene qin codes for a transcriptional repressor". Cancer Res. 55 (23): 5540–4. PMID 7585630. 
• Wiese S, Murphy DB, Schlung A, et al. (1995). "The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q". Biochim. Biophys. Acta 1262 (2–3): 105–12. PMID 7599184. 
• Pierrou S, Hellqvist M, Samuelsson L, et al. (1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". EMBO J. 13 (20): 5002–12. PMC 395442. PMID 7957066. 
• Li J, Vogt PK (1993). "The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4490–4. doi:10.1073/pnas.90.10.4490. PMC 46537. PMID 8099441. 
• Kastury K, Li J, Druck T, et al. (1994). "The human homologue of the retroviral oncogene qin maps to chromosome 14q13". Proc. Natl. Acad. Sci. U.S.A. 91 (9): 3616–8. doi:10.1073/pnas.91.9.3616. PMC 43631. PMID 8170957. 
• Huh S, Hatini V, Marcus RC, et al. (1999). "Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression". Dev. Biol. 211 (1): 53–63. doi:10.1006/dbio.1999.9303. PMID 10373304. 
• Dou CL, Li S, Lai E (1999). "Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres". Cereb. Cortex 9 (6): 543–50. doi:10.1093/cercor/9.6.543. PMID 10498272. 
• Dou C, Lee J, Liu B, et al. (2000). "BF-1 Interferes with Transforming Growth Factor β Signaling by Associating with Smad Partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097. 
• Yao J, Lai E, Stifani S (2001). "The Winged-Helix Protein Brain Factor 1 Interacts with Groucho and Hes Proteins To Repress Transcription". Mol. Cell. Biol. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMC 86788. PMID 11238932. 
• Rodriguez C, Huang LJ, Son JK, et al. (2001). "Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling". J. Biol. Chem. 276 (32): 30224–30. doi:10.1074/jbc.M102759200. PMID 11387330. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
• Tan K, Shaw AL, Madsen B, et al. (2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9". J. Biol. Chem. 278 (23): 20507–13. doi:10.1074/jbc.M301994200. PMID 12657635. 
• Seoane J, Le HV, Shen L, et al. (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation". Cell 117 (2): 211–23. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259. 
• Shoichet SA, Kunde SA, Viertel P, et al. (2005). "Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly". Hum. Genet. 117 (6): 536–44. doi:10.1007/s00439-005-1310-3. PMID 16133170. 

External links

• FOXG1B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.