POU3F1

POU class 3 homeobox 1
Identifiers
Symbols	POU3F1; OCT6; OTF6; SCIP
External IDs	OMIM: 602479 MGI: 101896 HomoloGene: 20590 GeneCards: POU3F1 Gene
Gene Ontology Molecular function • RNA polymerase II transcription coactivator activity • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • axon ensheathment • positive regulation of gene expression • myelination in peripheral nervous system • keratinocyte differentiation • forebrain development • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5453	18991
Ensembl	ENSG00000185668	ENSMUSG00000090125
UniProt	Q03052	P21952
RefSeq (mRNA)	NM_002699	NM_011141
RefSeq (protein)	NP_002690	NP_035271
Location (UCSC)	Chr 1: 38.51 – 38.51 Mb	Chr 4: 124.66 – 124.66 Mb
PubMed search	[1]	[2]

POU domain, class 3, transcription factor 1 is a protein that in humans is encoded by the POU3F1 gene.

See also

• Octamer transcription factor

Further reading

• Monuki ES, Kuhn R, Weinmaster G, et al. (1990). "Expression and activity of the POU transcription factor SCIP.". Science 249 (4974): 1300–3. doi:10.1126/science.1975954. PMID 1975954. 
• Suzuki N, Rohdewohld H, Neuman T, et al. (1990). "Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.". EMBO J. 9 (11): 3723–32. PMC 552128. PMID 1976514. 
• Zwilling S, König H, Wirth T (1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.". EMBO J. 14 (6): 1198–208. PMC 398197. PMID 7720710. 
• Leger H, Sock E, Renner K, et al. (1995). "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y.". Mol. Cell. Biol. 15 (7): 3738–47. PMC 230612. PMID 7791781. 
• Faus I, Hsu HJ, Fuchs E (1994). "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.". Mol. Cell. Biol. 14 (5): 3263–75. PMC 358693. PMID 7909356. 
• Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E (1996). "Expression of transcription regulating genes in human preimplantation embryos.". Hum. Reprod. 10 (10): 2787–92. PMID 8567814. 
• Jaegle M, Mandemakers W, Broos L, et al. (1996). "The POU factor Oct-6 and Schwann cell differentiation.". Science 273 (5274): 507–10. doi:10.1126/science.273.5274.507. PMID 8662541. 
• Sock E, Enderich J, Rosenfeld MG, Wegner M (1996). "Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6.". J. Biol. Chem. 271 (29): 17512–8. doi:10.1074/jbc.271.29.17512. PMID 8663425. 
• Malik KF, Jaffe H, Brady J, Young WS (1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.". Brain Res. Mol. Brain Res. 45 (1): 99–107. doi:10.1016/S0169-328X(96)00238-0. PMID 9105675. 
• Sumiyama K, Washio-Watanabe K, Ono T, et al. (1998). "Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2.". Mamm. Genome 9 (2): 180–1. doi:10.1007/s003359900721. PMID 9457692. 
• Arroyo EJ, Bermingham JR, Rosenfeld MG, Scherer SS (1998). "Promyelinating Schwann cells express Tst-1/SCIP/Oct-6.". J. Neurosci. 18 (19): 7891–902. PMID 9742157. 
• Kawasaki T, Oka N, Tachibana H, et al. (2003). "Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies.". Acta Neuropathol. 105 (3): 203–8. doi:10.1007/s00401-002-0630-9. PMID 12557005. 
• Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013. 
• Ryu EJ, Wang JY, Le N, et al. (2007). "Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.". J. Neurosci. 27 (43): 11552–9. doi:10.1523/JNEUROSCI.5497-06.2007. PMID 17959798. 

External links

• POU3F1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.