ARID2

AT rich interactive domain 2 (ARID, RFX-like)
Identifiers
Symbols	ARID2; BAF200; p200
External IDs	OMIM: 609539 MGI: 1924294 HomoloGene: 14601 GeneCards: ARID2 Gene
Gene Ontology Molecular function • DNA binding • protein binding • zinc ion binding • metal ion binding Cellular component • nucleus Biological process • nucleosome disassembly • transcription, DNA-dependent • regulation of transcription, DNA-dependent • chromatin modification Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	196528	77044
Ensembl	ENSG00000189079	ENSMUSG00000033237
UniProt	Q68CP9	E9Q6E3
RefSeq (mRNA)	NM_152641	NM_175251
RefSeq (protein)	NP_689854	NP_780460
Location (UCSC)	Chr 12: 46.12 – 46.3 Mb	Chr 15: 96.29 – 96.4 Mb
PubMed search	[1]	[2]

AT-rich interactive domain-containing protein 2 is a protein that in humans is encoded by the ARID2 gene.

ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.

Model organisms

Arid2 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Abnormal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal
Citrobacter infection	Normal
All tests and analysis from

Model organisms have been used in the study of ARID2 function. A conditional knockout mouse line, called Arid2^{tm1a(EUCOMM)Wtsi} was generated as part of the International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on mutant adult mice and two significant abnormalities were observed. A recessive lethal study found less homozygous mutant embryos during gestation than predicted by Mendelian ratio. In a second study, no homozygous mutant animals survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; these displayed no abnormalities.

Further reading

• Martens JA, Winston F (2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes.". Curr. Opin. Genet. Dev. 13 (2): 136–42. doi:10.1016/S0959-437X(03)00022-4. PMID 12672490. 
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Mohrmann L, Langenberg K, Krijgsveld J, et al. (2004). "Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes.". Mol. Cell. Biol. 24 (8): 3077–88. doi:10.1128/MCB.24.8.3077-3088.2004. PMC 381637. PMID 15060132. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Diederichs S, Bäumer N, Ji P, et al. (2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.". J. Biol. Chem. 279 (32): 33727–41. doi:10.1074/jbc.M401708200. PMID 15159402. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins.". Nucleic Acids Res. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446. 
• Wilsker D, Probst L, Wain HM, et al. (2005). "Nomenclature of the ARID family of DNA-binding proteins.". Genomics 86 (2): 242–51. doi:10.1016/j.ygeno.2005.03.013. PMID 15922553. 
• Yan Z, Cui K, Murray DM, et al. (2005). "PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.". Genes Dev. 19 (14): 1662–7. doi:10.1101/gad.1323805. PMC 1176002. PMID 15985610. 
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
• Zhang X, Azhar G, Zhong Y, Wei JY (2006). "Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation.". Biochem. Biophys. Res. Commun. 346 (3): 794–801. doi:10.1016/j.bbrc.2006.05.211. PMID 16782067. 

External links

• ARID2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.