CDX1
From Wikipedia, the free encyclopedia
| Caudal type homeobox 1 | ||||||||
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| Identifiers | ||||||||
| Symbols | CDX1; MGC116915 | |||||||
| External IDs | OMIM: 600746 MGI: 88360 HomoloGene: 1366 GeneCards: CDX1 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 1044 | 12590 | ||||||
| Ensembl | ENSG00000113722 | ENSMUSG00000024619 | ||||||
| UniProt | P47902 | P18111 | ||||||
| RefSeq (mRNA) | NM_001804 | NM_009880 | ||||||
| RefSeq (protein) | NP_001795 | NP_034010 | ||||||
| Location (UCSC) | Chr 5: 149.55 – 149.57 Mb |
Chr 18: 61.02 – 61.04 Mb |
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| PubMed search | [1] | [2] | ||||||
Homeobox protein CDX-1 is a protein that in humans is encoded by the CDX1 gene.[1][2]
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.[2]
[edit] References
- ^ Bonner CA, Loftus SK, Wasmuth JJ (Feb 1996). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027.
- ^ a b "Entrez Gene: CDX1 caudal type homeobox transcription factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1044.
[edit] Further reading
- Dixon, Jill; Edwards, Sara J.; Gladwin, Amanda J.; Dixon, Michael J.; Loftus, Stacie K.; Bonner, Cynthia A.; Koprivnikar, Kathryn; Wasmuth, John J. (1996). "Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group". Nat. Genet. 12 (2): 130–6. doi:10.1038/ng0296-130. PMID 8563749.
- Mallo GV, Rechreche H, Frigerio JM, et al. (1997). "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis". Int. J. Cancer 74 (1): 35–44. doi:10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1. PMID 9036867.
- Mizoshita T, Inada K, Tsukamoto T, et al. (2002). "Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach". Gastric Cancer 4 (4): 185–91. doi:10.1007/PL00011741. PMID 11846061.
- Suh ER, Ha CS, Rankin EB, et al. (2002). "DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines". J. Biol. Chem. 277 (39): 35795–800. doi:10.1074/jbc.M205567200. PMID 12124393.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Domon-Dell C, Schneider A, Moucadel V, et al. (2003). "Cdx1 homeobox gene during human colon cancer progression". Oncogene 22 (39): 7913–21. doi:10.1038/sj.onc.1206756. PMID 12970739.
- Wong NA, Britton MP, Choi GS, et al. (2004). "Loss of CDX1 expression in colorectal carcinoma: Promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines". Proc. Natl. Acad. Sci. U.S.A. 101 (2): 574–9. doi:10.1073/pnas.0307190101. PMC 327189. PMID 14704280.
- Rankin EB, Xu W, Silberg DG, Suh E (2004). "Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (5): G872–80. doi:10.1152/ajpgi.00326.2003. PMID 14715525.
- Béland M, Pilon N, Houle M, et al. (2004). "Cdx1 Autoregulation Is Governed by a Novel Cdx1-LEF1 Transcription Complex". Mol. Cell. Biol. 24 (11): 5028–38. doi:10.1128/MCB.24.11.5028-5038.2004. PMC 416402. PMID 15143193.
- Guo RJ, Huang E, Ezaki T, et al. (2004). "Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity". J. Biol. Chem. 279 (35): 36865–75. doi:10.1074/jbc.M405213200. PMID 15215241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Alkhoury F, Malo MS, Mozumder M, et al. (2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G285–90. doi:10.1152/ajpgi.00037.2005. PMID 15774940.
- Wong NA, Wilding J, Bartlett S, et al. (2005). "CDX1 is an important molecular mediator of Barrett's metaplasia". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7565–70. doi:10.1073/pnas.0502031102. PMC 1140438. PMID 15894614.
[edit] External links
- CDX1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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