GTF2E1

General transcription factor IIE, polypeptide 1, alpha 56kDa
PDB rendering based on 1vd4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1VD4, 2JTX, 2RNQ, 2RNR
Identifiers
Symbols	GTF2E1; FE; TF2E1; TFIIE-A
External IDs	OMIM: 189962 MGI: 1921447 HomoloGene: 38062 GeneCards: GTF2E1 Gene
Gene Ontology Molecular function • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular component • nucleoplasm Biological process • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • gene expression • viral reproduction • virus-host interaction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2960	74197
Ensembl	ENSG00000153767	ENSMUSG00000022828
UniProt	P29083	Q9D0D5
RefSeq (mRNA)	NM_005513	NM_028812
RefSeq (protein)	NP_005504	NP_083088
Location (UCSC)	Chr 3: 120.46 – 120.5 Mb	Chr 16: 37.51 – 37.54 Mb
PubMed search	[1]	[2]

General transcription factor IIE subunit 1 (GTF2E1), also known as transcription initiation factor IIE subunit alpha (TFIIE-alpha), is a protein that in humans is encoded by the GTF2E1 gene.

See also

• Transcription factor II E

Further reading

• Jeronimo C, Forget D, Bouchard A et al. (2007). "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme". Mol. Cell 27 (2): 262–74. doi:10.1016/j.molcel.2007.06.027. PMID 17643375. 
• Langelier MF, Forget D, Rojas A et al. (2001). "Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II". J. Biol. Chem. 276 (42): 38652–7. doi:10.1074/jbc.M106422200. PMID 11509574. 
• Vega A, Salas A, Milne RL et al. (2009). "Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study". Gynecol. Oncol. 112 (1): 210–4. doi:10.1016/j.ygyno.2008.09.012. PMID 18950845. 
• Yamamoto S, Watanabe Y, van der Spek PJ et al. (2001). "Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation". Mol. Cell. Biol. 21 (1): 1–15. doi:10.1128/MCB.21.1.1-15.2001. PMC 86563. PMID 11113176. 
• Watanabe T, Hayashi K, Tanaka A et al. (2003). "The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II". Mol. Cell. Biol. 23 (8): 2914–26. PMC 152561. PMID 12665589. 
• Jawhari A, Uhring M, De Carlo S et al. (2006). "Structure and oligomeric state of human transcription factor TFIIE". EMBO Rep. 7 (5): 500–5. doi:10.1038/sj.embor.7400663. PMC 1479554. PMID 16547462. 
• Orphanides G, Lagrange T, Reinberg D (1996). "The general transcription factors of RNA polymerase II". Genes Dev. 10 (21): 2657–83. doi:10.1101/gad.10.21.2657. PMID 8946909. 
• Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
• Archambault J, Pan G, Dahmus GK et al. (1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293. 
• Kim TK, Ebright RH, Reinberg D (2000). "Mechanism of ATP-dependent promoter melting by transcription factor IIH". Science 288 (5470): 1418–22. doi:10.1126/science.288.5470.1418. PMID 10827951. 
• Ikeda K, Halle JP, Stelzer G et al. (1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Mol. Cell. Biol. 18 (1): 10–8. PMC 121442. PMID 9418848. 
• Yu X, Li P, Roeder RG, Wang Z (2001). "Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split". Mol. Cell. Biol. 21 (14): 4614–25. doi:10.1128/MCB.21.14.4614-4625.2001. PMC 87125. PMID 11416139. 
• Di Lello P, Miller Jenkins LM, Mas C et al. (2008). "p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 106–11. doi:10.1073/pnas.0707892105. PMC 2224167. PMID 18160537. 
• Liu L, Ishihara K, Ichimura T et al. (2009). "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity". J. Biol. Chem. 284 (8): 5165–74. doi:10.1074/jbc.M807098200. PMID 19106100. 
• Okamoto T, Yamamoto S, Watanabe Y et al. (1998). "Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit". J. Biol. Chem. 273 (31): 19866–76. doi:10.1074/jbc.273.31.19866. PMID 9677423. 
• Okuda M, Tanaka A, Arai Y et al. (2004). "A novel zinc finger structure in the large subunit of human general transcription factor TFIIE". J. Biol. Chem. 279 (49): 51395–403. doi:10.1074/jbc.M404722200. PMID 15385556. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Okuda M, Tanaka A, Satoh M et al. (2008). "Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH". EMBO J. 27 (7): 1161–71. doi:10.1038/emboj.2008.47. PMC 2275666. PMID 18354501. 
• Fraser RA, Heard DJ, Adam S et al. (1998). "The putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors". J. Biol. Chem. 273 (26): 16199–204. doi:10.1074/jbc.273.26.16199. PMID 9632676. 
• Ravasi T, Suzuki H, Cannistraci CV et al. (2010). "An atlas of combinatorial transcriptional regulation in mouse and man". Cell 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142.