CREB1

CAMP responsive element binding protein 1
	; PDB rendering based on 1dh3.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1dh3
Identifiers
Symbols	CREB1; CREB
External IDs	OMIM: 123810 MGI: 88494 HomoloGene: 3223 ChEMBL: 5587 GeneCards: CREB1 Gene
Gene Ontology
Molecular function	• RNA polymerase II distal enhancer sequence-specific DNA binding; • RNA polymerase II activating transcription factor binding; • RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; • double-stranded DNA binding; • sequence-specific DNA binding transcription factor activity; • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; • transcription cofactor activity; • protein binding; • cAMP response element binding;
Cellular component	• nucleus; • nucleoplasm; • transcription factor complex; • nuclear euchromatin; • nucleolus; • mitochondrion;
Biological process	• toll-like receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • protein phosphorylation; • signal transduction; • epidermal growth factor receptor signaling pathway; • transforming growth factor beta receptor signaling pathway; • activation of phospholipase C activity; • synaptic transmission; • axon guidance; • lactation; • Toll signaling pathway; • regulation of cell size; • fibroblast growth factor receptor signaling pathway; • response to organic substance; • negative regulation of transcription by competitive promoter binding; • virus-host interaction; • pituitary gland development; • positive regulation of transforming growth factor beta3 production; • toll-like receptor 1 signaling pathway; • toll-like receptor 2 signaling pathway; • toll-like receptor 3 signaling pathway; • toll-like receptor 4 signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • positive regulation of multicellular organism growth; • response to drug; • regulation of circadian rhythm; • regulation of apoptotic process; • innate immune response; • positive regulation of fat cell differentiation; • positive regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of hormone secretion; • positive regulation of lipid biosynthetic process; • nerve growth factor receptor signaling pathway; • phosphatidylinositol-mediated signaling; • protein stabilization; • stress-activated MAPK cascade;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.^[1]^[2] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[3]

[edit] See also

CREB

[edit] Interactions

CREB1 has been shown to interact with HTATIP ,^[4] RPS6KA5 ,^[5]^[6] CREB binding protein ,^[7]^[8]^[9]^[10]^[11]^[12]^[13]^[14]^[15]^[16] FHL2 ,^[17] FHL3 ,^[17] P53 ,^[13] CEBPB ^[18] and FHL5 .^[17]

[edit] References

^ Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (December 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science 242 (4884): 1430–3. doi:10.1126/science.2974179. PMID 2974179.
^ Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (July 1990). "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics 7 (3): 416–21. doi:10.1016/0888-7543(90)90176-U. PMID 2142119.
^ "Entrez Gene: CREB1 cAMP responsive element binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1385.
^ Gavaravarapu, S; Kamine J (March 2000). "Tip60 inhibits activation of CREB protein by protein kinase A". Biochem. Biophys. Res. Commun. (UNITED STATES) 269 (3): 758–66. doi:10.1006/bbrc.2000.2358. ISSN 0006-291X. PMID 10720489.
^ Deak, M; Clifton A D, Lucocq L M, Alessi D R (August 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. (ENGLAND) 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. ISSN 0261-4189. PMC 1170775. PMID 9687510.
^ Wang, X; Li W, Williams M, Terada N, Alessi D R, Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". EMBO J. (England) 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.
^ Shi, Yuling; Venkataraman Sujatha L, Dodson Gerald E, Mabb Angela M, LeBlanc Scott, Tibbetts Randal S (April 2004). "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress". Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (16): 5898–903. doi:10.1073/pnas.0307718101. ISSN 0027-8424. PMC 395895. PMID 15073328.
^ Kim, J; Jia L, Stallcup M R, Coetzee G A (February 2005). "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus". J. Mol. Endocrinol. (England) 34 (1): 107–18. doi:10.1677/jme.1.01701. ISSN 0952-5041. PMID 15691881.
^ Shimomura, A; Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (July 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". J. Biol. Chem. (UNITED STATES) 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. ISSN 0021-9258. PMID 8663317.
^ Radhakrishnan, I; Pérez-Alvarado G C, Parker D, Dyson H J, Montminy M R, Wright P E (December 1997). "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell (UNITED STATES) 91 (6): 741–52. doi:10.1016/S0092-8674(00)80463-8. ISSN 0092-8674. PMID 9413984.
^ Sano, Y; Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (October 1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". J. Biol. Chem. (UNITED STATES) 273 (44): 29098–105. doi:10.1074/jbc.273.44.29098. ISSN 0021-9258. PMID 9786917.
^ Zor, Tsaffrir; Mayr Bernhard M, Dyson H Jane, Montminy Marc R, Wright Peter E (November 2002). "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators". J. Biol. Chem. (United States) 277 (44): 42241–8. doi:10.1074/jbc.M207361200. ISSN 0021-9258. PMID 12196545.
^ ^a ^b Giebler, H A; Lemasson I, Nyborg J K (July 2000). "p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4849–58. doi:10.1128/MCB.20.13.4849-4858.2000. ISSN 0270-7306. PMC 85936. PMID 10848610.
^ Zhang, Q; Vo N, Goodman R H (July 2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Mol. Cell. Biol. (UNITED STATES) 20 (14): 4970–8. doi:10.1128/MCB.20.14.4970-4978.2000. ISSN 0270-7306. PMC 85947. PMID 10866654.
^ Ernst, P; Wang J, Huang M, Goodman R H, Korsmeyer S J (April 2001). "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Mol. Cell. Biol. (United States) 21 (7): 2249–58. doi:10.1128/MCB.21.7.2249-2258.2001. ISSN 0270-7306. PMC 86859. PMID 11259575.
^ Ledo, Fran; Kremer Leonor, Mellström Britt, Naranjo Jose R (September 2002). "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM". EMBO J. (England) 21 (17): 4583–92. doi:10.1093/emboj/cdf440. ISSN 0261-4189. PMC 126180. PMID 12198160.
^ ^a ^b ^c Fimia, G M; De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. ISSN 0270-7306. PMC 102166. PMID 11046156.
^ Chen, Yongchang; Zhuang Shunhui, Cassenaer Stijn, Casteel Darren E, Gudi Tanima, Boss Gerry R, Pilz Renate B (June 2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Mol. Cell. Biol. (United States) 23 (12): 4066–82. doi:10.1128/MCB.23.12.4066-4082.2003. ISSN 0270-7306. PMC 156132. PMID 12773552.

[edit] Further reading

Don J, Stelzer G (2003). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis.". Mol. Cell. Endocrinol. 187 (1–2): 115–24. doi:10.1016/S0303-7207(01)00696-7. PMID 11988318.
Pandey SC (2005). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction". Pharmacol. Ther. 104 (1): 47–58. doi:10.1016/j.pharmthera.2004.08.002. PMID 15500908.
Wu H, Zhou Y, Xiong ZQ (2007). "Transducer of regulated CREB and late phase long-term synaptic potentiation". FEBS J. 274 (13): 3218–23. doi:10.1111/j.1742-4658.2007.05891.x. PMID 17565597.
Kitagawa K (2007). "CREB and cAMP response element-mediated gene expression in the ischemic brain". FEBS J. 274 (13): 3210–7. doi:10.1111/j.1742-4658.2007.05890.x. PMID 17565598.
Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". FEBS J. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
Siu YT, Jin DY (2007). "CREB--a real culprit in oncogenesis". FEBS J. 274 (13): 3224–32. doi:10.1111/j.1742-4658.2007.05884.x. PMID 17565603.

[edit] External links

CREB1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it.

[pmid2974179-1] Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (December 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science 242 (4884): 1430–3. doi:10.1126/science.2974179. PMID 2974179.

[pmid2142119-2] Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (July 1990). "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics 7 (3): 416–21. doi:10.1016/0888-7543(90)90176-U. PMID 2142119.

[3] "Entrez Gene: CREB1 cAMP responsive element binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1385.

[pmid10720489-4] Gavaravarapu, S; Kamine J (March 2000). "Tip60 inhibits activation of CREB protein by protein kinase A". Biochem. Biophys. Res. Commun. (UNITED STATES) 269 (3): 758–66. doi:10.1006/bbrc.2000.2358. ISSN 0006-291X. PMID 10720489.

[pmid9687510-5] Deak, M; Clifton A D, Lucocq L M, Alessi D R (August 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. (ENGLAND) 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. ISSN 0261-4189. PMC 1170775. PMID 9687510.

[pmid11500364-6] Wang, X; Li W, Williams M, Terada N, Alessi D R, Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". EMBO J. (England) 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

[pmid15073328-7] Shi, Yuling; Venkataraman Sujatha L, Dodson Gerald E, Mabb Angela M, LeBlanc Scott, Tibbetts Randal S (April 2004). "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress". Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (16): 5898–903. doi:10.1073/pnas.0307718101. ISSN 0027-8424. PMC 395895. PMID 15073328.

[pmid15691881-8] Kim, J; Jia L, Stallcup M R, Coetzee G A (February 2005). "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus". J. Mol. Endocrinol. (England) 34 (1): 107–18. doi:10.1677/jme.1.01701. ISSN 0952-5041. PMID 15691881.

[pmid8663317-9] Shimomura, A; Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (July 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". J. Biol. Chem. (UNITED STATES) 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. ISSN 0021-9258. PMID 8663317.

[pmid9413984-10] Radhakrishnan, I; Pérez-Alvarado G C, Parker D, Dyson H J, Montminy M R, Wright P E (December 1997). "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell (UNITED STATES) 91 (6): 741–52. doi:10.1016/S0092-8674(00)80463-8. ISSN 0092-8674. PMID 9413984.

[pmid9786917-11] Sano, Y; Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (October 1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". J. Biol. Chem. (UNITED STATES) 273 (44): 29098–105. doi:10.1074/jbc.273.44.29098. ISSN 0021-9258. PMID 9786917.

[pmid12196545-12] Zor, Tsaffrir; Mayr Bernhard M, Dyson H Jane, Montminy Marc R, Wright Peter E (November 2002). "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators". J. Biol. Chem. (United States) 277 (44): 42241–8. doi:10.1074/jbc.M207361200. ISSN 0021-9258. PMID 12196545.

[pmid10848610-13] Giebler, H A; Lemasson I, Nyborg J K (July 2000). "p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4849–58. doi:10.1128/MCB.20.13.4849-4858.2000. ISSN 0270-7306. PMC 85936. PMID 10848610.

[pmid10866654-14] Zhang, Q; Vo N, Goodman R H (July 2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Mol. Cell. Biol. (UNITED STATES) 20 (14): 4970–8. doi:10.1128/MCB.20.14.4970-4978.2000. ISSN 0270-7306. PMC 85947. PMID 10866654.

[pmid11259575-15] Ernst, P; Wang J, Huang M, Goodman R H, Korsmeyer S J (April 2001). "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Mol. Cell. Biol. (United States) 21 (7): 2249–58. doi:10.1128/MCB.21.7.2249-2258.2001. ISSN 0270-7306. PMC 86859. PMID 11259575.

[pmid12198160-16] Ledo, Fran; Kremer Leonor, Mellström Britt, Naranjo Jose R (September 2002). "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM". EMBO J. (England) 21 (17): 4583–92. doi:10.1093/emboj/cdf440. ISSN 0261-4189. PMC 126180. PMID 12198160.

[pmid11046156-17] Fimia, G M; De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. ISSN 0270-7306. PMC 102166. PMID 11046156.

[pmid12773552-18] Chen, Yongchang; Zhuang Shunhui, Cassenaer Stijn, Casteel Darren E, Gudi Tanima, Boss Gerry R, Pilz Renate B (June 2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Mol. Cell. Biol. (United States) 23 (12): 4066–82. doi:10.1128/MCB.23.12.4066-4082.2003. ISSN 0270-7306. PMC 156132. PMID 12773552.

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CREB1

Contents

[edit] See also

[edit] Interactions

[edit] References

[edit] Further reading

[edit] External links

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