CNBP

CCHC-type zinc finger, nucleic acid binding protein
Identifiers
Symbols	CNBP; CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9
External IDs	OMIM: 116955 MGI: 88431 HomoloGene: 2567 GeneCards: CNBP Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • zinc ion binding • metal ion binding Cellular component • nucleus • endoplasmic reticulum • cytosol Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • cholesterol biosynthetic process • positive regulation of cell proliferation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7555	12785
Ensembl	ENSG00000169714	ENSMUSG00000030057
UniProt	P62633	P53996
RefSeq (mRNA)	NM_001127192	NM_001109745
RefSeq (protein)	NP_001120664	NP_001103215
Location (UCSC)	Chr 3: 128.89 – 128.9 Mb	Chr 6: 87.84 – 87.85 Mb
PubMed search	[1]	[2]

Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM]

External links

• GeneReviews/NCBI/NIH/UW entry on Myotonic Dystrophy Type 2
• ZNF9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

References

Rajavashisth TB, Taylor AK, Andalibi A, et al. (1989). "Identification of a zinc finger protein that binds to the sterol regulatory element.". Science 245 (4918): 640–3. doi:10.1126/science.2562787. PMID 2562787.

Further reading

Rajavashisth TB, Taylor AK, Andalibi A, et al. (1989). "Identification of a zinc finger protein that binds to the sterol regulatory element.". Science 245 (4918): 640–3. doi:10.1126/science.2562787. PMID 2562787.

• Rajavashisth TB, Taylor AK, Andalibi A, et al. (1989). "Identification of a zinc finger protein that binds to the sterol regulatory element.". Science 245 (4918): 640–3. doi:10.1126/science.2562787. PMID 2562787. 
• Flink IL, Morkin E (1995). "Organization of the gene encoding cellular nucleic acid-binding protein.". Gene 163 (2): 279–82. doi:10.1016/0378-1119(95)00421-2. PMID 7590281. 
• Warden CH, Krisans SK, Purcell-Huynh D, et al. (1995). "Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing.". Genomics 24 (1): 14–9. doi:10.1006/geno.1994.1576. PMID 7896269. 
• Ricker K, Grimm T, Koch MC, et al. (1999). "Linkage of proximal myotonic myopathy to chromosome 3q.". Neurology 52 (1): 170–1. PMID 9921867. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• McGrath CF, Buckman JS, Gagliardi TD, et al. (2003). "Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein.". J. Virol. 77 (15): 8524–31. doi:10.1128/JVI.77.15.8524-8531.2003. PMC 165261. PMID 12857921. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Vallo L, Bonifazi E, Borgiani P, et al. (2005). "Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population.". Mol. Cell. Probes 19 (1): 71–4. doi:10.1016/j.mcp.2004.09.003. PMID 15652222. 
• Botta A, Caldarola S, Vallo L, et al. (2006). "Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2).". Biochim. Biophys. Acta 1762 (3): 329–34. doi:10.1016/j.bbadis.2005.11.004. PMID 16376058. 
• Margolis JM, Schoser BG, Moseley ML, et al. (2006). "DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression.". Hum. Mol. Genet. 15 (11): 1808–15. doi:10.1093/hmg/ddl103. PMID 16624843. 
• Toth C, Dunham C, Suchowersky O, et al. (2007). "Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2.". Muscle Nerve 35 (2): 259–64. doi:10.1002/mus.20685. PMID 17068784. 
• Gerbasi VR, Link AJ (2007). "The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation.". Mol. Cell Proteomics 6 (6): 1049–58. doi:10.1074/mcp.M600384-MCP200. PMID 17327219. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.