MTF1

Metal-regulatory transcription factor 1
Identifiers
Symbols	MTF1; MTF-1; ZRF
External IDs	OMIM: 600172 MGI: 101786 HomoloGene: 4347 GeneCards: MTF1 Gene
Gene Ontology Molecular function • RNA polymerase II core promoter sequence-specific DNA binding • core promoter binding • DNA binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • protein binding • zinc ion binding • histone acetyltransferase binding • metal ion binding Cellular component • nucleus • nucleolus Biological process • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • response to oxidative stress • response to metal ion • positive regulation of transcription from RNA polymerase II promoter • response to cadmium ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4520	17764
Ensembl	ENSG00000188786	ENSMUSG00000028890
UniProt	Q14872	Q07243
RefSeq (mRNA)	NM_005955	NM_008636
RefSeq (protein)	NP_005946	NP_032662
Location (UCSC)	Chr 1: 38.28 – 38.33 Mb	Chr 4: 124.8 – 124.85 Mb
PubMed search	[1]	[2]

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).

Further reading

• Westin G, Schaffner W (1989). "A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene.". EMBO J. 7 (12): 3763–70. PMC 454951. PMID 3208749. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Chen X, Chu M, Giedroc DP (1999). "MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex". Biochemistry 38 (39): 12915–25. doi:10.1021/bi9913000. PMID 10504263. 
• Otsuka F, Okugaito I, Ohsawa M, et al. (2000). "Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals". Biochim. Biophys. Acta 1492 (2–3): 330–40. PMID 11004505. 
• Saydam N, Georgiev O, Nakano MY, et al. (2001). "Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals". J. Biol. Chem. 276 (27): 25487–95. doi:10.1074/jbc.M009154200. PMID 11306562. 
• Saydam N, Adams TK, Steiner F, et al. (2002). "Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription". J. Biol. Chem. 277 (23): 20438–45. doi:10.1074/jbc.M110631200. PMID 11923282. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Majumder S, Ghoshal K, Summers D, et al. (2003). "Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1". J. Biol. Chem. 278 (28): 26216–26. doi:10.1074/jbc.M302887200. PMC 2365495. PMID 12716893. 
• Saydam N, Steiner F, Georgiev O, Schaffner W (2003). "Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1". J. Biol. Chem. 278 (34): 31879–83. doi:10.1074/jbc.M302138200. PMID 12805380. 
• Chen X, Zhang B, Harmon PM, et al. (2004). "A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo". J. Biol. Chem. 279 (6): 4515–22. doi:10.1074/jbc.M308924200. PMID 14610091. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Balamurugan K, Egli D, Selvaraj A, et al. (2005). "Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison". Biol. Chem. 385 (7): 597–603. doi:10.1515/BC.2004.074. PMID 15318808. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene 24 (13): 2204–17. doi:10.1038/sj.onc.1208206. PMID 15735762. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 

External links

• MTF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.