ZNF148

Zinc finger protein 148
Identifiers
Symbols	ZNF148; BERF-1; BFCOL1; HT-BETA; ZBP-89; ZFP148; pHZ-52
External IDs	OMIM: 601897 MGI: 1332234 HomoloGene: 8003 GeneCards: ZNF148 Gene
Gene Ontology Molecular function • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular component • nucleus • nucleolus • Golgi apparatus Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • protein complex assembly • cellular defense response • gamete generation • negative regulation of gene expression • negative regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7707	22661
Ensembl	ENSG00000163848	ENSMUSG00000022811
UniProt	Q9UQR1	Q61624
RefSeq (mRNA)	NM_021964	NM_011749
RefSeq (protein)	NP_068799	NP_035879
Location (UCSC)	Chr 3: 124.94 – 125.09 Mb	Chr 16: 33.38 – 33.5 Mb
PubMed search	[1]	[2]

Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene.

Interactions

ZNF148 has been shown to interact with PTRF and P53.

See also

• Zinc finger

Further reading

• Wang Y, Kobori JA, Hood L (1993). "The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression". Mol. Cell. Biol. 13 (9): 5691–701. PMC 360303. PMID 8355710. 
• Merchant JL, Iyer GR, Taylor BR, et al. (1997). "ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter". Mol. Cell. Biol. 16 (12): 6644–53. PMC 231666. PMID 8943318. 
• Taniuchi T, Mortensen ER, Ferguson A, et al. (1997). "Overexpression of ZBP-89, a zinc finger DNA binding protein, in gastric cancer". Biochem. Biophys. Res. Commun. 233 (1): 154–60. doi:10.1006/bbrc.1997.6310. PMID 9144414. 
• Law DJ, Tarlé SA, Merchant JL (1998). "The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression". Mamm. Genome 9 (2): 165–7. doi:10.1007/s003359900711. PMID 9457682. 
• Law GL, Itoh H, Law DJ, et al. (1998). "Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter". J. Biol. Chem. 273 (32): 19955–64. doi:10.1074/jbc.273.32.19955. PMID 9685330. 
• Ye S, Whatling C, Watkins H, Henney A (1999). "Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89". FEBS Lett. 450 (3): 268–72. doi:10.1016/S0014-5793(99)00509-8. PMID 10359087. 
• Hasegawa T, Takeuchi A, Miyaishi O, et al. (2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". Biochem. J. 347 Pt 1 (Pt 1): 55–9. doi:10.1042/0264-6021:3470055. PMC 1220930. PMID 10727401. 
• Bai L, Merchant JL (2000). "Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells". J. Biol. Chem. 275 (39): 30725–33. doi:10.1074/jbc.M004249200. PMID 10899165. 
• Bai L, Merchant JL (2001). "ZBP-89 Promotes Growth Arrest through Stabilization of p53". Mol. Cell. Biol. 21 (14): 4670–83. doi:10.1128/MCB.21.14.4670-4683.2001. PMC 87140. PMID 11416144. 
• Park H, Shelley CS, Arnaout MA (2003). "The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene". Blood 101 (3): 894–902. doi:10.1182/blood-2002-03-0680. PMID 12393719. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Chen GG, Merchant JL, Lai PB, et al. (2003). "Mutation of p53 in Recurrent Hepatocellular Carcinoma and Its Association with the Expression of ZBP-89". Am. J. Pathol. 162 (6): 1823–9. doi:10.1016/S0002-9440(10)64317-9. PMC 1868140. PMID 12759240. 
• Wu Y, Diab I, Zhang X, et al. (2004). "Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89". Oncogene 23 (1): 168–78. doi:10.1038/sj.onc.1207003. PMID 14712222. 
• Bai L, Yoon SO, King PD, Merchant JL (2005). "ZBP-89-induced apoptosis is p53-independent and requires JNK". Cell Death Differ. 11 (6): 663–73. doi:10.1038/sj.cdd.4401393. PMID 14963412. 
• Samuelsson L, Stiller C, Friberg C, et al. (2004). "Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5". J. Invest. Dermatol. 122 (6): 1399–400. doi:10.1046/j.0022-202X.2004.12604.x. PMID 15175029. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 

External links

• ZNF148 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.