BHLHB2

Basic helix-loop-helix family, member e40
Identifiers
Symbols	BHLHE40; BHLHB2; DEC1; HLHB2; SHARP-2; STRA13; Stra14
External IDs	OMIM: 604256 MGI: 1097714 HomoloGene: 2722 GeneCards: BHLHE40 Gene
Gene Ontology Molecular function • sequence-specific DNA binding RNA polymerase II transcription factor activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription • sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • protein binding • protein domain specific binding • protein homodimerization activity • bHLH transcription factor binding • MRF binding • protein heterodimerization activity • E-box binding Cellular component • nucleus • nucleolus • Golgi apparatus Biological process • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • circadian regulation of gene expression • entrainment of circadian clock by photoperiod • negative regulation of sequence-specific DNA binding transcription factor activity • regulation of neuronal synaptic plasticity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8553	20893
Ensembl	ENSG00000134107	ENSMUSG00000030103
UniProt	O14503	O35185
RefSeq (mRNA)	NM_003670	NM_011498
RefSeq (protein)	NP_003661	NP_035628
Location (UCSC)	Chr 3: 5.02 – 5.03 Mb	Chr 6: 108.66 – 108.67 Mb
PubMed search	[1]	[2]

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.

DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.

Further reading

• Teramoto M, Nakamasu K, Noshiro M, et al. (2001). "Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2.". J. Biochem. 129 (3): 391–6. PMID 11226878. 
• Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (2001). "Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway.". J. Biol. Chem. 276 (18): 15306–15. doi:10.1074/jbc.M010516200. PMID 11278694. 
• Sun H, Lu B, Li RQ, et al. (2001). "Defective T cell activation and autoimmune disorder in Stra13-deficient mice.". Nat. Immunol. 2 (11): 1040–7. doi:10.1038/ni721. PMID 11668339. 
• Yoon DY, Buchler P, Saarikoski ST, et al. (2001). "Identification of genes differentially induced by hypoxia in pancreatic cancer cells.". Biochem. Biophys. Res. Commun. 288 (4): 882–6. doi:10.1006/bbrc.2001.5867. PMID 11688991. 
• Li Y, Zhang H, Xie M, et al. (2002). "Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation.". Biochem. J. 367 (Pt 2): 413–22. doi:10.1042/BJ20020514. PMC 1222902. PMID 12119049. 
• St-Pierre B, Flock G, Zacksenhaus E, Egan SE (2003). "Stra13 homodimers repress transcription through class B E-box elements.". J. Biol. Chem. 277 (48): 46544–51. doi:10.1074/jbc.M111652200. PMID 12297495. 
• Miyazaki K, Kawamoto T, Tanimoto K, et al. (2003). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes.". J. Biol. Chem. 277 (49): 47014–21. doi:10.1074/jbc.M204938200. PMID 12354771. 
• Shen M, Yoshida E, Yan W, et al. (2003). "Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages.". J. Biol. Chem. 277 (51): 50112–20. doi:10.1074/jbc.M206771200. PMID 12384505. 
• Honma S, Kawamoto T, Takagi Y, et al. (2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock.". Nature 419 (6909): 841–4. doi:10.1038/nature01123. PMID 12397359. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Li Y, Xie M, Song X, et al. (2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter.". J. Biol. Chem. 278 (19): 16899–907. doi:10.1074/jbc.M300596200. PMID 12624110. 
• Giatromanolaki A, Koukourakis MI, Sivridis E, et al. (2003). "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.". J. Pathol. 200 (2): 222–8. doi:10.1002/path.1330. PMID 12754744. 
• Ivanova AV, Ivanov SV, Zhang X, et al. (2004). "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets.". J. Mol. Biol. 340 (4): 641–53. doi:10.1016/j.jmb.2004.05.025. PMID 15223310. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Sato F, Kawamoto T, Fujimoto K, et al. (2005). "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.". Eur. J. Biochem. 271 (22): 4409–19. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782. 
• Ivanova AV, Ivanov SV, Lerman ML (2005). "Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins.". Cell. Mol. Life Sci. 62 (4): 471–84. doi:10.1007/s00018-004-4423-2. PMID 15719173. 
• Ivanova A, Liao SY, Lerman MI, et al. (2006). "STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker.". J. Med. Genet. 42 (7): 565–76. doi:10.1136/jmg.2004.029835. PMC 1736099. PMID 15994878. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 

External links

• BHLHB2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook BHLHE40

This article incorporates text from the United States National Library of Medicine, which is in the public domain.