MAFG

V-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
PDB rendering based on 1k1v.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1k1v
Identifiers
Symbols	MAFG; hMAF
External IDs	OMIM: 602020 MGI: 96911 HomoloGene: 81816 GeneCards: MAFG Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleoplasm Biological process • in utero embryonic development • transcription, DNA-dependent • blood coagulation • adult behavior • regulation of cellular pH • regulation of cell proliferation • regulation of epidermal cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4097	17134
Ensembl	ENSG00000197063	ENSMUSG00000051510
UniProt	O15525	O54790
RefSeq (mRNA)	NM_002359	NM_010756
RefSeq (protein)	NP_002350	NP_034886
Location (UCSC)	Chr 17: 79.88 – 79.89 Mb	Chr 11: 120.63 – 120.63 Mb
PubMed search	[1]	[2]

Transcription factor MafG is a protein that in humans is encoded by the MAFG gene.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Johnsen O, Skammelsrud N, Luna L, et al. (1996). "Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1". Nucleic Acids Res. 24 (21): 4289–97. doi:10.1093/nar/24.21.4289. PMC 146217. PMID 8932385. 
• Toki T, Itoh J, Kitazawa J, et al. (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif". Oncogene 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357. 
• Blank V, Kim MJ, Andrews NC (1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression". Blood 89 (11): 3925–35. PMID 9166829. 
• Marini MG, Chan K, Casula L, et al. (1997). "hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2". J. Biol. Chem. 272 (26): 16490–7. doi:10.1074/jbc.272.26.16490. PMID 9195958. 
• Blank V, Knoll JH, Andrews NC (1997). "Molecular characterization and localization of the human MAFG gene". Genomics 44 (1): 147–9. doi:10.1006/geno.1997.4847. PMID 9286713. 
• Johnsen O, Murphy P, Prydz H, Kolsto AB (1998). "Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription". Nucleic Acids Res. 26 (2): 512–20. doi:10.1093/nar/26.2.512. PMC 147270. PMID 9421508. 
• Dhakshinamoorthy S, Jaiswal AK (2001). "Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene". J. Biol. Chem. 275 (51): 40134–41. doi:10.1074/jbc.M003531200. PMID 11013233. 
• Kataoka K, Yoshitomo-Nakagawa K, Shioda S, Nishizawa M (2001). "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities". J. Biol. Chem. 276 (1): 819–26. doi:10.1074/jbc.M007643200. PMID 11036080. 
• Hung HL, Kim AY, Hong W, et al. (2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691. 
• Kusunoki H, Motohashi H, Katsuoka F, et al. (2002). "Solution structure of the DNA-binding domain of MafG". Nat. Struct. Biol. 9 (4): 252–6. doi:10.1038/nsb771. PMID 11875518. 
• Dhakshinamoorthy S, Jaiswal AK (2002). "c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction". Oncogene 21 (34): 5301–12. doi:10.1038/sj.onc.1205642. PMID 12149651. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Tramier M, Gautier I, Piolot T, et al. (2003). "Picosecond-hetero-FRET microscopy to probe protein-protein interactions in live cells". Biophys. J. 83 (6): 3570–7. doi:10.1016/S0006-3495(02)75357-5. PMC 1302432. PMID 12496124. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Yamamoto T, Kyo M, Kamiya T, et al. (2006). "Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements". Genes Cells 11 (6): 575–91. doi:10.1111/j.1365-2443.2006.00965.x. PMID 16716189. 

External links

• MAFG protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.