ING1
From Wikipedia, the free encyclopedia
| Inhibitor of growth family, member 1 | ||||||||
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| Identifiers | ||||||||
| Symbols | ING1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a | |||||||
| External IDs | OMIM: 601566 MGI: 1349481 HomoloGene: 40119 GeneCards: ING1 Gene | |||||||
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| RNA expression pattern | ||||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 3621 | 26356 | ||||||
| Ensembl | ENSG00000153487 | ENSMUSG00000045969 | ||||||
| UniProt | Q9UK53 | Q9QXV3 | ||||||
| RefSeq (mRNA) | NM_001267728 | NM_011919 | ||||||
| RefSeq (protein) | NP_001254657 | NP_036049 | ||||||
| Location (UCSC) | Chr 13: 111.37 – 111.37 Mb |
Chr 8: 11.56 – 11.56 Mb |
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| PubMed search | [1] | [2] | ||||||
Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3]
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
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[edit] Location on Chromosome 13
ING1 is located near the following genes on Chromosome 13
- CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
- COL4A2: A2 Subunit of type IV collagen
- RAB20: Potential regulator of Connexin 43 trafficking.
- CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2
[edit] Interactions
ING1 has been shown to interact with HDAC1,[4][5] DMAP1,[6] PCNA,[7] SIN3A,[5] SAP30,[5] P53,[8][9] SMARCC1,[5] CREB binding protein[4] and SMARCA4.[5]
[edit] References
- ^ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nat Genet 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021.
- ^ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenet Cell Genet 76 (3-4): 176–8. doi:10.1159/000134539. PMID 9186514.
- ^ a b "Entrez Gene: ING1 inhibitor of growth family, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3621.
- ^ a b Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug. 2002). "Human ING1 proteins differentially regulate histone acetylation". J. Biol. Chem. (United States) 277 (33): 29832–9. doi:10.1074/jbc.M200197200. ISSN 0021-9258. PMID 12015309.
- ^ a b c d e Kuzmichev, A; Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb. 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Mol. Cell. Biol. (United States) 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. ISSN 0270-7306. PMC 133546. PMID 11784859.
- ^ Xin, Huawei; Yoon Ho-Guen, Singh Prim B, Wong Jiemin, Qin Jun (Mar. 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". J. Biol. Chem. (United States) 279 (10): 9539–46. doi:10.1074/jbc.M311587200. ISSN 0021-9258. PMID 14665632.
- ^ Scott, M; Bonnefin P, Vieyra D, Boisvert F M, Young D, Bazett-Jones D P, Riabowol K (Oct. 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". J. Cell. Sci. (England) 114 (Pt 19): 3455–62. ISSN 0021-9533. PMID 11682605.
- ^ Leung, Ka Man; Po Lai See, Tsang Fan Cheung, Siu Wai Yi, Lau Anita, Ho Horace T B, Poon Randy Y C (Sep. 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Res. (United States) 62 (17): 4890–3. ISSN 0008-5472. PMID 12208736.
- ^ Garkavtsev, I; Grigorian I A, Ossovskaya V S, Chernov M V, Chumakov P M, Gudkov A V (Jan. 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature (ENGLAND) 391 (6664): 295–8. doi:10.1038/34675. ISSN 0028-0836. PMID 9440695.
[edit] Further reading
- Campos EI, Chin MY, Kuo WH, Li G (2004). "Biological functions of the ING family tumor suppressors.". Cell. Mol. Life Sci. 61 (19-20): 2597–613. doi:10.1007/s00018-004-4199-4. PMID 15526165.
- Helbing CC, Veillette C, Riabowol K, et al. (1997). "A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis.". Cancer Res. 57 (7): 1255–8. PMID 9102209.
- Garkavtsev I, Riabowol K (1997). "Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor.". Mol. Cell. Biol. 17 (4): 2014–9. PMC 232048. PMID 9121449.
- Zeremski M, Horrigan SK, Grigorian IA, et al. (1997). "Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34.". Somat. Cell Mol. Genet. 23 (3): 233–6. doi:10.1007/BF02721376. PMID 9330636.
- Garkavtsev I, Grigorian IA, Ossovskaya VS, et al. (1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control.". Nature 391 (6664): 295–8. doi:10.1038/34675. PMID 9440695.
- Shinoura N, Muramatsu Y, Nishimura M, et al. (1999). "Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas.". Cancer Res. 59 (21): 5521–8. PMID 10554029.
- Jäger D, Stockert E, Scanlan MJ, et al. (2000). "Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene.". Cancer Res. 59 (24): 6197–204. PMID 10626813.
- Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D (2000). "Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions.". Genes Chromosomes Cancer 27 (3): 319–22. doi:10.1002/(SICI)1098-2264(200003)27:3<319::AID-GCC13>3.0.CO;2-P. PMID 10679922.
- Tokunaga E, Maehara Y, Oki E, et al. (2000). "Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers.". Cancer Lett. 152 (1): 15–22. doi:10.1016/S0304-3835(99)00434-6. PMID 10754201.
- Baranova AV, Ivanov DV, Makeeva NV, et al. (2000). "[Genomic organization of the suppressor gene for tumor growth ING1]". Mol. Biol. (Mosk.) 34 (2): 263–9. PMID 10779953.
- Saito A, Furukawa T, Fukushige S, et al. (2000). "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.". J. Hum. Genet. 45 (3): 177–81. doi:10.1007/s100380050206. PMID 10807544.
- Gunduz M, Ouchida M, Fukushima K, et al. (2000). "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.". Cancer Res. 60 (12): 3143–6. PMID 10866301.
- Skowyra D, Zeremski M, Neznanov N, et al. (2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.". J. Biol. Chem. 276 (12): 8734–9. doi:10.1074/jbc.M007664200. PMID 11118440.
- Nagashima M, Shiseki M, Miura K, et al. (2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9671–6. doi:10.1073/pnas.161151798. PMC 55510. PMID 11481424.
- Scott M, Bonnefin P, Vieyra D, et al. (2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis.". J. Cell. Sci. 114 (Pt 19): 3455–62. PMID 11682605.
- Kuzmichev A, Zhang Y, Erdjument-Bromage H, et al. (2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).". Mol. Cell. Biol. 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. PMC 133546. PMID 11784859.
- Nouman GS, Angus B, Lunec J, et al. (2002). "Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues.". Hybrid. Hybridomics 21 (1): 1–10. doi:10.1089/15368590252917584. PMID 11991811.
- Bromidge T, Lynas C (2002). "Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies.". Leuk. Res. 26 (7): 631–5. doi:10.1016/S0145-2126(01)00185-0. PMID 12008079.
[edit] External links
- ING1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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