Eomesodermin

Eomesodermin
Identifiers
Symbols	EOMES; TBR2
External IDs	OMIM: 604615 HomoloGene: 3971 GeneCards: EOMES Gene
Gene Ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription • DNA binding • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • endoderm formation • mesoderm formation • endodermal cell fate specification • trophectodermal cell differentiation • CD8-positive, alpha-beta T cell differentiation involved in immune response • brain development • stem cell maintenance • olfactory bulb development • cerebral cortex neuron differentiation • interferon-gamma production • positive regulation of cell differentiation • regulation of neuron differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • cell differentiation involved in embryonic placenta development • mesodermal to mesenchymal transition involved in gastrulation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8320	13813
Ensembl	ENSG00000163508	ENSMUSG00000032446
UniProt	O95936	O54839
RefSeq (mRNA)	NM_005442	NM_001164789
RefSeq (protein)	NP_005433	NP_001158261
Location (UCSC)	Chr 3: 27.76 – 27.76 Mb	Chr 9: 118.48 – 118.49 Mb
PubMed search	[1]	[2]

Eomesodermin also known as T-box brain protein 2 (TBR2) is a protein that in humans is encoded by the EOMES gene.

This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.

See also

• T-box family
• TBR1

Further reading

• Kimura, N.; Nakashima, K.; Ueno, M.; Kiyama, H.; Taga, T. (1999). "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain". Brain research. Developmental brain research 115 (2): 183–193. PMID 10407135. 
• Intlekofer, A. M.; Takemoto, N.; Wherry, E. J.; Longworth, S. A.; Northrup, J. T.; Palanivel, V. R.; Mullen, A. C.; Gasink, C. R. et al. (2005). "Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin". Nature Immunology 6 (12): 1236–1244. doi:10.1038/ni1268. PMID 16273099. 
• Baala, L.; Briault, S.; Etchevers, H. C.; Laumonnier, F. D. R.; Natiq, A.; Amiel, J.; Boddaert, N.; Picard, C. et al. (2007). "Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis". Nature Genetics 39 (4): 454–456. doi:10.1038/ng1993. PMID 17353897. 
• Atreya, I.; Schimanski, C. C.; Becker, C.; Wirtz, S.; Dornhoff, H.; Schnurer, E.; Berger, M. R.; Galle, P. R. et al. (2007). "The T‐box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer". Gut 56 (11): 1572–1578. doi:10.1136/gut.2006.117812. PMC 2095672. PMID 17566017. 
• Araki, Y.; Fann, M.; Wersto, R.; Weng, N. P. (2008). "Histone Acetylation Facilitates Rapid and Robust Memory CD8 T Cell Response through Differential Expression of Effector Molecules (Eomesodermin and Its Targets: Perforin and Granzyme B)". Journal of immunology (Baltimore, Md. : 1950) 180 (12): 8102–8108. PMC 2493419. PMID 18523274. 
• Sessa, A.; Mao, C. A.; Hadjantonakis, A. K.; Klein, W. H.; Broccoli, V. (2008). "Tbr2 Directs Conversion of Radial Glia into Basal Precursors and Guides Neuronal Amplification by Indirect Neurogenesis in the Developing Neocortex". Neuron 60 (1): 56–69. doi:10.1016/j.neuron.2008.09.028. PMC 2887762. PMID 18940588. 
• d’Cruz, L. M.; Rubinstein, M. P.; Goldrath, A. W. (2009). "Surviving the crash: Transitioning from effector to memory CD8+ T cell". Seminars in Immunology 21 (2): 92–98. doi:10.1016/j.smim.2009.02.002. PMC 2671236. PMID 19269192. 
• Wang, H. T.; Ge, X. S.; Xue, Z. P.; Li, B. Q. (2010). "Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets". Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 26 (1): 31–34. PMID 20056084. 
• Narayanan, S.; Silva, R.; Peruzzi, G.; Alvarez, Y.; Simhadri, V. R.; Debell, K.; Coligan, J. E.; Borrego, F. (2010). "Human Th1 Cells That Express CD300a Are Polyfunctional and After Stimulation Up-Regulate the T-Box Transcription Factor Eomesodermin". In Unutmaz, Derya. PLoS ONE 5 (5): e10636. doi:10.1371/journal.pone.0010636. PMC 2869357. PMID 20498708. 
• Kinjyo, I.; Gordon, S. M.; Intlekofer, A. M.; Dowdell, K.; Mooney, E. C.; Caricchio, R.; Grupp, S. A.; Teachey, D. T. et al. (2010). "Lymphoproliferation Caused by Fas Deficiency is Dependent on the Transcription Factor Eomesodermin". The Journal of Immunology 185 (12): 7151–7155. doi:10.4049/jimmunol.1003193. PMC 2997140. PMID 21076068. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.