NFIX
From Wikipedia, the free encyclopedia
| Nuclear factor I/X (CCAAT-binding transcription factor) | |||
|---|---|---|---|
| Identifiers | |||
| Symbols | NFIX; MRSHSS; NF1A; SOTOS2 | ||
| External IDs | OMIM: 164005 MGI: 97311 HomoloGene: 1872 GeneCards: NFIX Gene | ||
| RNA expression pattern | |||
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| More reference expression data | |||
| Orthologs | |||
| Species | Human | Mouse | |
| Entrez | 4784 | 18032 | |
| Ensembl | ENSG00000008441 | ENSMUSG00000001911 | |
| UniProt | Q14938 | P70257 | |
| RefSeq (mRNA) | NM_001271043 | NM_001081981 | |
| RefSeq (protein) | NP_001257972 | NP_001075450 | |
| Location (UCSC) | Chr 19: 13.11 – 13.21 Mb |
Chr 8: 84.7 – 84.8 Mb |
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| PubMed search | [1] | [2] | |
Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene.[1][2][3] NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.[4]
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[edit] Interactions
NFIX has been shown to interact with SKI protein[5] and it is also known to interact with AP-1.[4] NFI-X3 has been shown to interact with STAT3.[4]
[edit] References
- ^ Seisenberger C, Winnacker EL, Scherthan H (Aug 1993). "Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH". Hum Genet 91 (6): 535–7. PMID 8340106.
- ^ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
- ^ "Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4784.
- ^ a b c Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T (November 2011). "A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40". J. Biol. Chem. 286 (46): 39893–903. doi:10.1074/jbc.M111.257451. PMID 21953450.
- ^ Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (October 1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.
[edit] Further reading
- Apt D, Liu Y, Bernard HU (1994). "Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner.". Nucleic Acids Res. 22 (19): 3825–33. doi:10.1093/nar/22.19.3825. PMC 308376. PMID 7937100.
- Sumner C, Shinohara T, Durham L, et al. (1996). "Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes.". J. Neurovirol. 2 (2): 87–100. doi:10.3109/13550289609146542. PMID 8799200.
- Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein.". J. Biol. Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
- Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.
- Tarapore P, Richmond C, Zheng G, et al. (1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI.". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.
- Müller K, Mermod N (2000). "The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo.". J. Biol. Chem. 275 (3): 1645–50. doi:10.1074/jbc.275.3.1645. PMID 10636857.
- Nakazato M, Chung HK, Ulianich L, et al. (2000). "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression.". Mol. Cell. Biol. 20 (22): 8499–512. doi:10.1128/MCB.20.22.8499-8512.2000. PMC 102156. PMID 11046146.
- Imagawa M, Sakaue R, Tanabe A, et al. (2000). "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A.". FEBS Lett. 484 (2): 118–24. doi:10.1016/S0014-5793(00)02119-0. PMID 11068044.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Gopalan SM, Wilczynska KM, Konik BS, et al. (2006). "Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes.". J. Biol. Chem. 281 (19): 13126–33. doi:10.1074/jbc.M601194200. PMID 16565071.
- Ravichandran V, Sabath BF, Jensen PN, et al. (2006). "Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism.". J. Virol. 80 (21): 10506–13. doi:10.1128/JVI.01355-06. PMC 1641797. PMID 16928756.
[edit] External links
- NFIX protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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