NKX2-3

NK2 homeobox 3
Identifiers
Symbols	NKX2-3; CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3
External IDs	OMIM: 606727 MGI: 97348 HomoloGene: 17061 GeneCards: NKX2-3 Gene
Gene Ontology Molecular function • molecular_function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • cellular_component • nucleus Biological process • leukocyte homeostasis • plasma cell differentiation • transcription, DNA-dependent • triglyceride metabolic process • biological_process • gland morphogenesis • macrophage differentiation • regulation of cell proliferation • odontogenesis of dentin-containing tooth • CD4-positive, alpha-beta T cell differentiation • positive regulation of transcription from RNA polymerase II promoter • lymph node development • spleen development • Peyer's patch development • post-embryonic digestive tract morphogenesis • leukocyte migration Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	159296	18089
Ensembl	ENSG00000119919	ENSMUSG00000044220
UniProt	Q8TAU0	P97334
RefSeq (mRNA)	NM_145285	NM_008699
RefSeq (protein)	NP_660328	NP_032725
Location (UCSC)	Chr 10: 101.29 – 101.3 Mb	Chr 19: 43.61 – 43.62 Mb
PubMed search	[1]	[2]

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.

Further reading

• Harvey RP (1996). "NK-2 homeobox genes and heart development.". Dev. Biol. 178 (2): 203–16. doi:10.1006/dbio.1996.0212. PMID 8812123. 
• Pabst O, Zweigerdt R, Arnold HH (1999). "Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen.". Development 126 (10): 2215–25. PMID 10207146. 
• Phiel CJ, Gabbeta V, Parsons LM et al. (2001). "Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues". J. Biol. Chem. 276 (37): 34637–50. doi:10.1074/jbc.M105826200. PMID 11457859. 
• Biben C, Wang CC, Harvey RP (2003). "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis". Int. J. Dev. Biol. 46 (4): 415–22. PMID 12141427. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.