JARID1B

Lysine (K)-specific demethylase 5B
Identifiers
Symbols	KDM5B; CT31; JARID1B; PLU-1; PLU1; PUT1; RBBP2H1A
External IDs	OMIM: 605393 MGI: 1922855 HomoloGene: 48448 GeneCards: KDM5B Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • transcription corepressor activity • protein binding • zinc ion binding • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors • histone demethylase activity (H3-trimethyl-K4 specific) • histone demethylase activity (H3-dimethyl-K4 specific) • metal ion binding Cellular component • nucleus • nucleolus • intracellular membrane-bounded organelle Biological process • transcription, DNA-dependent • histone H3-K4 demethylation • histone H3-K4 demethylation, trimethyl-H3-K4-specific • negative regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10765	75605
Ensembl	ENSG00000117139	ENSMUSG00000042207
UniProt	Q9UGL1	Q80Y84
RefSeq (mRNA)	NM_006618	NM_152895
RefSeq (protein)	NP_006609	NP_690855
Location (UCSC)	Chr 1: 202.7 – 202.78 Mb	Chr 1: 134.56 – 134.63 Mb
PubMed search	[1]	[2]

Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene.

Interactions

JARID1B has been shown to interact with FOXG1 and PAX9.

Further reading

• Lu PJ, Sundquist K, Baeckstrom D, et al. (1999). "A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.". J. Biol. Chem. 274 (22): 15633–45. doi:10.1074/jbc.274.22.15633. PMID 10336460. 
• Kashuba V, Protopopov A, Podowski R, et al. (2000). "Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A).". Eur. J. Hum. Genet. 8 (6): 407–13. doi:10.1038/sj.ejhg.5200474. PMID 10878660. 
• Barrett A, Madsen B, Copier J, et al. (2002). "PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?". Int. J. Cancer 101 (6): 581–8. doi:10.1002/ijc.10644. PMID 12237901. 
• Tan K, Shaw AL, Madsen B, et al. (2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.". J. Biol. Chem. 278 (23): 20507–13. doi:10.1074/jbc.M301994200. PMID 12657635. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Res. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446. 
• Tzschach A, Lenzner S, Moser B, et al. (2006). "Novel JARID1C/SMCX mutations in patients with X-linked mental retardation". Hum. Mutat. 27 (4): 389. doi:10.1002/humu.9420. PMID 16541399. 
• Yamane K, Tateishi K, Klose RJ, et al. (2007). "PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation". Mol. Cell 25 (6): 801–12. doi:10.1016/j.molcel.2007.03.001. PMID 17363312. 
• Barrett A, Santangelo S, Tan K, et al. (2007). "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases". Int. J. Cancer 121 (2): 265–75. doi:10.1002/ijc.22673. PMID 17373667. 

External links

• JARID1B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.