HHEX

Hematopoietically expressed homeobox
PDB rendering based on 2e1o.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E1O
Identifiers
Symbols	HHEX; HEX; HMPH; HOX11L-PEN; PRH; PRHX
External IDs	OMIM: 604420 MGI: 96086 HomoloGene: 31110 GeneCards: HHEX Gene
Gene Ontology Molecular function • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • transcription factor binding • eukaryotic initiation factor 4E binding • DNA binding, bending • TBP-class protein binding • protein homodimerization activity • sequence-specific DNA binding • transcription regulatory region DNA binding • repressing transcription factor binding • HMG box domain binding Cellular component • nucleus • cytoplasm • protein-DNA complex Biological process • negative regulation of transcription from RNA polymerase II promoter • vasculogenesis • in utero embryonic development • myeloid leukocyte differentiation • transcription, DNA-dependent • mRNA export from nucleus • cell cycle • endoderm development • cell proliferation • response to wounding • anterior/posterior pattern specification • negative regulation of transcription by transcription factor localization • negative regulation of transcription by competitive promoter binding • Wnt receptor signaling pathway • negative regulation of angiogenesis • poly(A)+ mRNA export from nucleus • interkinetic nuclear migration • cell differentiation • positive regulation of Wnt receptor signaling pathway • B cell differentiation • thyroid gland development • negative regulation of vascular endothelial growth factor receptor signaling pathway • pancreas development • protein localization to nucleus • embryonic heart tube development • multicellular organism growth • regulation of cell proliferation • response to peptide hormone stimulus • negative regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • embryonic organ development • forebrain morphogenesis • primary lung bud formation • common bile duct development • gall bladder development • hepatic duct development • hepatoblast differentiation • hepatocyte differentiation • DNA conformation change • primitive streak formation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3087	15242
Ensembl	ENSG00000152804	ENSMUSG00000024986
UniProt	Q03014	P43120
RefSeq (mRNA)	NM_002729	NM_008245
RefSeq (protein)	NP_002720	NP_032271
Location (UCSC)	Chr 10: 94.45 – 94.46 Mb	Chr 19: 37.43 – 37.44 Mb
PubMed search	[1]	[2]

Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene.

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.

Interactions

HHEX has been shown to interact with Promyelocytic leukemia protein.

Further reading

• Neidle S, Goodwin GH (1994). "A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells". FEBS Lett. 345 (2–3): 93–8. doi:10.1016/0014-5793(94)00446-3. PMID 7911091. 
• Crompton MR, Bartlett TJ, MacGregor AD et al. (1993). "Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells". Nucleic Acids Res. 20 (21): 5661–7. doi:10.1093/nar/20.21.5661. PMC 334400. PMID 1360645. 
• Manfioletti G, Gattei V, Buratti E et al. (1995). "Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells". Blood 85 (5): 1237–45. PMID 7858254. 
• Topcu Z, Mack DL, Hromas RA, Borden KL (2000). "The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control". Oncogene 18 (50): 7091–100. doi:10.1038/sj.onc.1203201. PMID 10597310. 
• Pellizzari L, D'Elia A, Rustighi A et al. (2000). "Expression and function of the homeodomain-containing protein Hex in thyroid cells". Nucleic Acids Res. 28 (13): 2503–11. doi:10.1093/nar/28.13.2503. PMC 102703. PMID 10871399. 
• Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–82. doi:10.1074/jbc.M102552200. PMID 11551904. 
• Morgutti M, Demori E, Pecile V et al. (2001). "Genomic organization and chromosome mapping of the human homeobox gene HHEX". Cytogenet. Cell Genet. 94 (1–2): 30–2. doi:10.1159/000048778. PMID 11701950. 
• D'Elia AV, Tell G, Russo D et al. (2002). "Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors". J. Clin. Endocrinol. Metab. 87 (3): 1376–83. doi:10.1210/jc.87.3.1376. PMID 11889211. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Topisirovic I, Culjkovic B, Cohen N et al. (2003). "The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth". EMBO J. 22 (3): 689–703. doi:10.1093/emboj/cdg069. PMC 140753. PMID 12554669. 
• Nakagawa T, Abe M, Yamazaki T et al. (2003). "HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro". Arterioscler. Thromb. Vasc. Biol. 23 (2): 231–7. doi:10.1161/01.ATV.0000052670.55321.87. PMID 12588764. 
• Puppin C, D'Elia AV, Pellizzari L et al. (2003). "Thyroid-specific transcription factors control Hex promoter activity". Nucleic Acids Res. 31 (7): 1845–52. doi:10.1093/nar/gkg295. PMC 152810. PMID 12655000. 
• Bess KL, Swingler TE, Rivett AJ et al. (2003). "The transcriptional repressor protein PRH interacts with the proteasome". Biochem. J. 374 (Pt 3): 667–75. doi:10.1042/BJ20030769. PMC 1223646. PMID 12826010. 
• George A, Morse HC, Justice MJ (2003). "The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells". Oncogene 22 (43): 6764–73. doi:10.1038/sj.onc.1206822. PMID 14555989. 
• Minami T, Murakami T, Horiuchi K et al. (2004). "Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling". J. Biol. Chem. 279 (20): 20626–35. doi:10.1074/jbc.M308730200. PMID 15016828. 
• Puppin C, Presta I, D'Elia AV et al. (2004). "Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter". Mol. Cell. Endocrinol. 214 (1–2): 117–25. doi:10.1016/j.mce.2003.10.061. PMID 15062550. 
• Swingler TE, Bess KL, Yao J et al. (2004). "The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells". J. Biol. Chem. 279 (33): 34938–47. doi:10.1074/jbc.M404488200. PMID 15187083. 

External links

• HHEX protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.