Transcription factor II B
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Transcription factor IIB (TFIIB) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is encoded by the TFIIB gene.[2][3]
Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between transcription factor IID, which initially recognizes the promoter sequence, and RNA polymerase II.[4] It is involved in the selection of the transcription start site; mutations in TFIIB cause a shift in the transcription start site.[5]
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[edit] Interactions
Transcription factor IIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID,[6][7] and the RPB1 subunit of RNA polymerase II.[7]
Transcription Factor IIB makes sequence-specific protein-DNA interactions with the B recognition element (BRE), a promoter element flanking the TATA element.[8][9] The role of TFIIB in the vast number of human promoters lacking TATA and BRE elements remains unclear.
Recent study shows that TFIIB links transcription inhibition with the p53-dependent DNA damage response. [10]
[edit] See also
[edit] References
- ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. p636–637. ISBN 0-13-144946-X.
- ^ Ha I, Lane WS, Reinberg D (1991). "Cloning of a human gene encoding the general transcription initiation factor IIB". Nature 352 (6337): 689–95. doi:10.1038/352689a0. PMID 1876184.
- ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
- ^ "Entrez Gene: GTF2B general transcription factor IIB". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2959.
- ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
- ^ Tang H, Sun X, Reinberg D, Ebright RH (1996). "Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (3): 1119–24. doi:10.1073/pnas.93.3.1119. PMC 40041. PMID 8577725.
- ^ a b Bushnell, David A; Westover KD, Davis RE, Kornberg RD (Feb. 2004). "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms". Science (United States) 303 (5660): 983–8. doi:10.1126/science.1090838. PMID 14963322.
- ^ Lagrange T, Kapanidis AN, Tang H, Reinberg D, Ebright RH (1998). "New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB". Genes and Development 12 (1): 34–44. doi:10.1101/gad.12.1.34. PMC 316406. PMID 9420329.
- ^ Littlefield O, Korkhin Y, Sigler PB (1999). "The structural basis for the oriented assembly of a TBP/TFB/promoter complex". Proceedings of the National Academy of Sciences of the USA 96 (24): 13668–13673. doi:10.1073/pnas.96.24.13668. PMC 24122. PMID 10570130.
- ^ "TFIIB dephosphorylation links transcription inhibition with the p53-dependent DNA damage response". doi:10.1073/pnas.1207483109. http://www.pnas.org/content/early/2012/10/30/1207483109.abstract. Retrieved 2 November 2012.
[edit] Further reading
- Roeder RG (1996). "The role of general initiation factors in transcription by RNA polymerase II.". Trends Biochem. Sci. 21 (9): 327–35. doi:10.1016/0968-0004(96)10050-5. PMID 8870495.
- Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
- Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
- Seelamgari A, Maddukuri A, Berro R, et al. (2006). "Role of viral regulatory and accessory proteins in HIV-1 replication.". Front. Biosci. 9: 2388–413. doi:10.2741/1403. PMID 15353294.
- Ing NH, Beekman JM, Tsai SY, et al. (1992). "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).". J. Biol. Chem. 267 (25): 17617–23. PMID 1517211.
- Malik S, Hisatake K, Sumimoto H, et al. (1991). "Sequence of general transcription factor TFIIB and relationships to other initiation factors.". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9553–7. doi:10.1073/pnas.88.21.9553. PMC 52756. PMID 1946368.
- Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788–92. doi:10.1073/pnas.92.13.5788. PMC 41586. PMID 7597030.
- Veschambre P, Simard P, Jalinot P (1995). "Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo.". J. Mol. Biol. 250 (2): 169–80. doi:10.1006/jmbi.1995.0368. PMID 7608968.
- Desai-Yajnik V, Hadzic E, Modlinger P, et al. (1995). "Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.". J. Virol. 69 (8): 5103–12. PMC 189328. PMID 7609079.
- Cavaillès V, Dauvois S, L'Horset F, et al. (1995). "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.". EMBO J. 14 (15): 3741–51. PMC 394449. PMID 7641693.
- Nakshatri H, Nakshatri P, Currie RA (1995). "Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter.". J. Biol. Chem. 270 (33): 19613–23. doi:10.1074/jbc.270.33.19613. PMID 7642649.
- Abendroth FD, Peterson SR, Galman M, et al. (1995). "Identification of human autoantibodies to transcription factor IIB.". Nucleic Acids Res. 23 (14): 2770–4. doi:10.1093/nar/23.14.2770. PMC 307103. PMID 7651839.
- Bagby S, Kim S, Maldonado E, et al. (1995). "Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein.". Cell 82 (5): 857–67. doi:10.1016/0092-8674(95)90483-2. PMID 7671313.
- Nikolov DB, Chen H, Halay ED, et al. (1995). "Crystal structure of a TFIIB-TBP-TATA-element ternary complex.". Nature 377 (6545): 119–28. doi:10.1038/377119a0. PMID 7675079.
- Schmitz ML, Stelzer G, Altmann H, et al. (1995). "Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators.". J. Biol. Chem. 270 (13): 7219–26. doi:10.1074/jbc.270.13.7219. PMID 7706261.
- Yu L, Zhang Z, Loewenstein PM, et al. (1995). "Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain.". J. Virol. 69 (5): 3007–16. PMC 189000. PMID 7707527.
- Yu L, Loewenstein PM, Zhang Z, Green M (1995). "In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP.". J. Virol. 69 (5): 3017–23. PMC 189001. PMID 7707528.
- Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.
- Franklin CC, McCulloch AV, Kraft AS (1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.". Biochem. J. 305 (3): 967–74. PMC 1136352. PMID 7848298.
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[edit] External links
- Transcription Factor TFIIB at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook GTF2B
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