PHF1
From Wikipedia, the free encyclopedia
| PHD finger protein 1 | ||||||||
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| Identifiers | ||||||||
| Symbols | PHF1; MTF2L2; PCL1; PHF2; TDRD19C | |||||||
| External IDs | OMIM: 602881 MGI: 98647 HomoloGene: 7567 GeneCards: PHF1 Gene | |||||||
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| RNA expression pattern | ||||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 5252 | 21652 | ||||||
| Ensembl | ENSG00000112511 | ENSMUSG00000024193 | ||||||
| UniProt | O43189 | Q9Z1B8 | ||||||
| RefSeq (mRNA) | NM_002636 | NM_009343 | ||||||
| RefSeq (protein) | NP_002627 | NP_033369 | ||||||
| Location (UCSC) | Chr 6: 33.38 – 33.38 Mb |
Chr 17: 26.93 – 26.94 Mb |
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| PubMed search | [1] | [2] | ||||||
PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.[1][2][3]
This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.[3]
[edit] References
- ^ Coulson M, Robert S, Eyre HJ, Saint R (Jun 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics 48 (3): 381–3. doi:10.1006/geno.1997.5201. PMID 9545646.
- ^ Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Res 36 (9): 2939–47. doi:10.1093/nar/gkn146. PMC 2396414. PMID 18385154.
- ^ a b "Entrez Gene: PHF1 PHD finger protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5252.
[edit] Further reading
- Cao R, Wang H, He J, et al. (2008). "Role of hPHF1 in H3K27 Methylation and Hox Gene Silencing". Mol. Cell. Biol. 28 (5): 1862–72. doi:10.1128/MCB.01589-07. PMC 2258785. PMID 18086877.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- O'Connell S, Wang L, Robert S, et al. (2001). "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein". J. Biol. Chem. 276 (46): 43065–73. doi:10.1074/jbc.M104294200. PMID 11571280.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
[edit] External links
- PHF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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