ZNF43

Zinc finger protein 43
Identifiers
Symbols	ZNF43; HTF6; KOX27; ZNF39L1
External IDs	OMIM: 603972 MGI: 3040691 HomoloGene: 128170 GeneCards: ZNF43 Gene
Gene Ontology Molecular function • DNA binding • zinc ion binding • metal ion binding Cellular component • nucleus Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7594	408068
Ensembl	ENSG00000198521	ENSMUSG00000048280
UniProt	P17038	O88262
RefSeq (mRNA)	NM_001256648	NM_001001187.3
RefSeq (protein)	NP_001243577	NP_001001187.2
Location (UCSC)	Chr 19: 21.99 – 22.03 Mb	Chr 13: 67.67 – 67.69 Mb
PubMed search	[1]	[2]

Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.

See also

• Zinc finger

Further reading

• Huebner K, Druck T, Croce CM, Thiesen HJ (1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". Am. J. Hum. Genet. 48 (4): 726–40. PMC 1682948. PMID 2014798. 
• Bellefroid EJ, Poncelet DA, Lecocq PJ et al. (1991). "The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3608–12. doi:10.1073/pnas.88.9.3608. PMC 51501. PMID 2023909. 
• Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909. 
• Bellefroid EJ, Marine JC, Ried T et al. (1993). "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells". EMBO J. 12 (4): 1363–74. PMC 413348. PMID 8467795. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. 
• Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. 
• Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. 
• Takahashi T, Furuchi T, Naganuma A (2007). "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells". Cancer Res. 66 (24): 11932–7. doi:10.1158/0008-5472.CAN-06-3220. PMID 17178891. 

External links

• ZNF43 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.