ZNF350

Zinc finger protein 350
Identifiers
Symbols	ZNF350; ZBRK1; ZFQR
External IDs	OMIM: 605422 HomoloGene: 130723 GeneCards: ZNF350 Gene
Gene Ontology Molecular function • DNA binding • protein binding • zinc ion binding • metal ion binding Cellular component • nucleus • nucleolus • nuclear matrix • transcriptional repressor complex Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • negative regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59348	n/a
Ensembl	ENSG00000256683	n/a
UniProt	Q9GZX5	n/a
RefSeq (mRNA)	NM_021632	n/a
RefSeq (protein)	NP_067645	n/a
Location (UCSC)	Chr 19: 52.47 – 52.49 Mb	n/a
PubMed search	[1]	n/a

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.

Interactions

ZNF350 has been shown to interact with BRCA1.

See also

• Zinc finger

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Rutter JL, Smith AM, Dávila MR et al. (2004). "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals". Hum. Mutat. 22 (2): 121–8. doi:10.1002/humu.10238. PMID 12872252. 
• Yun J, Lee WH (2003). "Degradation of Transcription Repressor ZBRK1 through the Ubiquitin-Proteasome Pathway Relieves Repression of Gadd45a upon DNA Damage". Mol. Cell. Biol. 23 (20): 7305–14. doi:10.1128/MCB.23.20.7305-7314.2003. PMC 230312. PMID 14517299. 
• Tan W, Zheng L, Lee WH, Boyer TG (2004). "Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression". J. Biol. Chem. 279 (8): 6576–87. doi:10.1074/jbc.M312270200. PMID 14660588. 
• Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. 
• Tan W, Kim S, Boyer TG (2005). "Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1". J. Biol. Chem. 279 (53): 55153–60. doi:10.1074/jbc.M410926200. PMID 15496401. 
• Liao G, Huang J, Fixman ED, Hayward SD (2005). "The Epstein-Barr Virus Replication Protein BBLF2/3 Provides an Origin-Tethering Function through Interaction with the Zinc Finger DNA Binding Protein ZBRK1 and the KAP-1 Corepressor". J. Virol. 79 (1): 245–56. doi:10.1128/JVI.79.1.245-256.2005. PMC 538732. PMID 15596820. 
• Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
• Bulliard Y, Wiznerowicz M, Barde I, Trono D (2007). "KRAB can repress lentivirus proviral transcription independently of integration site". J. Biol. Chem. 281 (47): 35742–6. doi:10.1074/jbc.M602843200. PMID 16997916. 
• Desjardins S, Belleau P, Labrie Y et al. (2007). "Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families". Int. J. Cancer 122 (1): 108–16. doi:10.1002/ijc.23058. PMID 17764113. 

External links

• ZNF350 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.