NFE2L1
From Wikipedia, the free encyclopedia
| Nuclear factor (erythroid-derived 2)-like 1 | ||||||||
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| Identifiers | ||||||||
| Symbols | NFE2L1; LCR-F1; NRF1; TCF11 | |||||||
| External IDs | OMIM: 163260 MGI: 99421 HomoloGene: 20685 GeneCards: NFE2L1 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 4779 | 18023 | ||||||
| Ensembl | ENSG00000082641 | ENSMUSG00000038615 | ||||||
| UniProt | Q14494 | Q61985 | ||||||
| RefSeq (mRNA) | NM_003204 | NM_001130450 | ||||||
| RefSeq (protein) | NP_003195 | NP_001123922 | ||||||
| Location (UCSC) | Chr 17: 46.13 – 46.14 Mb |
Chr 11: 96.82 – 96.83 Mb |
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| PubMed search | [1] | [2] | ||||||
Nuclear factor erythroid 2-related factor 1 is a protein that in humans is encoded by the NFE2L1 gene.[1][2][3]
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[edit] Interactions
NFE2L1 has been shown to interact with C-jun.[4]
[edit] References
- ^ Chan JY, Han XL, Kan YW (Jan 1994). "Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast". Proc Natl Acad Sci U S A 90 (23): 11371–5. doi:10.1073/pnas.90.23.11371. PMC 47984. PMID 8248256.
- ^ Chan JY, Kwong M, Lu R, Chang J, Wang B, Yen TS, Kan YW (Apr 1998). "Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice". EMBO J 17 (6): 1779–87. doi:10.1093/emboj/17.6.1779. PMC 1170525. PMID 9501099.
- ^ "Entrez Gene: NFE2L1 nuclear factor (erythroid-derived 2)-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4779.
- ^ Venugopal, R; Jaiswal A K (Dec. 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene (ENGLAND) 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. ISSN 0950-9232. PMID 9872330.
[edit] Further reading
- Luna L, Skammelsrud N, Johnsen O et al. (1995). "Structural organization and mapping of the human TCF11 gene". Genomics 27 (2): 237–44. doi:10.1006/geno.1995.1037. PMID 7557987.
- Luna L, Johnsen O, Skartlien AH et al. (1995). "Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22". Genomics 22 (3): 553–62. doi:10.1006/geno.1994.1428. PMID 8001966.
- Caterina JJ, Donze D, Sun CW et al. (1994). "Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression". Nucleic Acids Res. 22 (12): 2383–91. doi:10.1093/nar/22.12.2383. PMC 523699. PMID 8036168.
- Johnsen O, Skammelsrud N, Luna L et al. (1996). "Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1". Nucleic Acids Res. 24 (21): 4289–97. doi:10.1093/nar/24.21.4289. PMC 146217. PMID 8932385.
- Toki T, Itoh J, Kitazawa J et al. (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif". Oncogene 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.
- Johnsen O, Murphy P, Prydz H, Kolsto AB (1998). "Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription". Nucleic Acids Res. 26 (2): 512–20. doi:10.1093/nar/26.2.512. PMC 147270. PMID 9421508.
- Novotny V, Prieschl EE, Csonga R et al. (1999). "Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells". Nucleic Acids Res. 26 (23): 5480–5. doi:10.1093/nar/26.23.5480. PMC 147998. PMID 9826775.
- Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.
- Murphy P, Kolstø A (2001). "Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development". Mech. Dev. 97 (1–2): 141–8. doi:10.1016/S0925-4773(00)00413-5. PMID 11025215.
- Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Husberg C, Murphy P, Bjørgo E et al. (2003). "Cellular localisation and nuclear export of the human bZIP transcription factor TCF11". Biochim. Biophys. Acta 1640 (2–3): 143–51. doi:10.1016/S0167-4889(03)00041-7. PMID 12729924.
- Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ma J, Dempsey AA, Stamatiou D et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
[edit] External links
- NFE2L1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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