N-Myc

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Identifiers
Symbols	MYCN; MODED; N-myc; NMYC; ODED; bHLHe37
External IDs	OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • protein dimerization activity Cellular component • chromatin • nucleus Biological process • cartilage condensation • positive regulation of mesenchymal cell proliferation • regulation of transcription from RNA polymerase II promoter • positive regulation of cell death • lung development • embryonic digit morphogenesis • positive regulation of transcription from RNA polymerase II promoter • embryonic skeletal system morphogenesis • negative regulation of astrocyte differentiation • branching morphogenesis of a tube • negative regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4613	18109
Ensembl	ENSG00000134323	ENSMUSG00000037169
UniProt	P04198	P03966
RefSeq (mRNA)	NM_005378	NM_008709
RefSeq (protein)	NP_005369	NP_032735
Location (UCSC)	Chr 2: 16.08 – 16.09 Mb	Chr 12: 12.94 – 12.94 Mb
PubMed search	[1]	[2]

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian), also known as MYCN, is a protein which in humans is encoded by the MYCN gene.

Function

This gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA.

Clinical significance

Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Interactions

N-Myc has been shown to interact with MAX.

N-Myc is also stabilized by Aurora A which protects it from degradation.

See also

• Myc

Further reading

• Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network.". Gene 277 (1-2): 1–14. doi:10.1016/S0378-1119(01)00697-7. PMID 11602341. 
• Armstrong BC, Krystal GW (1992). "Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.". Cell Growth Differ. 3 (6): 385–90. PMID 1419902. 
• Hagiwara T, Nakaya K, Nakamura Y, et al. (1992). "Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II.". Eur. J. Biochem. 209 (3): 945–50. doi:10.1111/j.1432-1033.1992.tb17367.x. PMID 1425701. 
• Fougerousse F, Meloni R, Roudaut C, Beckmann JS (1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1).". Nucleic Acids Res. 20 (5): 1165. doi:10.1093/nar/20.5.1165. PMC 312136. PMID 1549498. 
• Krystal GW, Armstrong BC, Battey JF (1990). "N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.". Mol. Cell. Biol. 10 (8): 4180–91. PMC 360949. PMID 1695323. 
• Blackwood EM, Eisenman RN (1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc.". Science 251 (4998): 1211–7. doi:10.1126/science.2006410. PMID 2006410. 
• Emanuel BS, Balaban G, Boyd JP, et al. (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas.". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423. 
• Ibson JM, Rabbitts PH (1988). "Sequence of a germ-line N-myc gene and amplification as a mechanism of activation.". Oncogene 2 (4): 399–402. PMID 2834684. 
• Stanton LW, Schwab M, Bishop JM (1986). "Nucleotide sequence of the human N-myc gene.". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1772–6. doi:10.1073/pnas.83.6.1772. PMC 323166. PMID 2869488. 
• Michitsch RW, Melera PW (1985). "Nucleotide sequence of the 3' exon of the human N-myc gene.". Nucleic Acids Res. 13 (7): 2545–58. doi:10.1093/nar/13.7.2545. PMC 341174. PMID 2987858. 
• Slamon DJ, Boone TC, Seeger RC, et al. (1986). "Identification and characterization of the protein encoded by the human N-myc oncogene.". Science 232 (4751): 768–72. doi:10.1126/science.3008339. PMID 3008339. 
• Garson JA, van den Berghe JA, Kemshead JT (1987). "Novel non-isotopic in situ hybridization technique detects small (1 Kb) unique sequences in routinely G-banded human chromosomes: fine mapping of N-myc and beta-NGF genes.". Nucleic Acids Res. 15 (12): 4761–70. doi:10.1093/nar/15.12.4761. PMC 305916. PMID 3299258. 
• Stanton LW, Bishop JM (1988). "Alternative processing of RNA transcribed from NMYC.". Mol. Cell. Biol. 7 (12): 4266–72. PMC 368108. PMID 3437890. 
• Kohl NE, Legouy E, DePinho RA, et al. (1986). "Human N-myc is closely related in organization and nucleotide sequence to c-myc.". Nature 319 (6048): 73–7. doi:10.1038/319073a0. PMID 3510398. 
• Grady EF, Schwab M, Rosenau W (1987). "Expression of N-myc and c-src during the development of fetal human brain.". Cancer Res. 47 (11): 2931–6. PMID 3552210. 
• Ramsay G, Stanton L, Schwab M, Bishop JM (1987). "Human proto-oncogene N-myc encodes nuclear proteins that bind DNA.". Mol. Cell. Biol. 6 (12): 4450–7. PMC 367228. PMID 3796607. 
• Brodeur GM, Seeger RC (1986). "Gene amplification in human neuroblastomas: basic mechanisms and clinical implications.". Cancer Genet. Cytogenet. 19 (1-2): 101–11. doi:10.1016/0165-4608(86)90377-8. PMID 3940169. 
• Kanda N, Schreck R, Alt F, et al. (1983). "Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 80 (13): 4069–73. doi:10.1073/pnas.80.13.4069. PMC 394202. PMID 6575396. 
• Schwab M, Varmus HE, Bishop JM, et al. (1984). "Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.". Nature 308 (5956): 288–91. doi:10.1038/308288a0. PMID 6700732. 
• Brodeur GM, Seeger RC, Schwab M, et al. (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.". Science 224 (4653): 1121–4. doi:10.1126/science.6719137. PMID 6719137. 

External links

• MYCN protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.