HOXB4

Homeobox B4
Identifiers
Symbols	HOXB4; HOX-2.6; HOX2; HOX2F
External IDs	OMIM: 142965 MGI: 96185 HomoloGene: 32095 GeneCards: HOXB4 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • morphogenesis of an epithelial sheet • transcription, DNA-dependent • regulation of transcription, DNA-dependent • multicellular organismal development • cell proliferation • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • somatic stem cell division • spleen development • bone marrow development • embryonic skeletal system morphogenesis • definitive hemopoiesis • hematopoietic stem cell differentiation • positive regulation of stem cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3214	15412
Ensembl	ENSG00000182742	ENSMUSG00000038692
UniProt	P17483	P10284
RefSeq (mRNA)	NM_024015	NM_010459
RefSeq (protein)	NP_076920	NP_034589
Location (UCSC)	Chr 17: 46.65 – 46.66 Mb	Chr 11: 96.32 – 96.32 Mb
PubMed search	[1]	[2]

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

See also

• Homeobox

Further reading

• Petrini M, Quaranta MT, Testa U, et al. (1992). "Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes". Blood 80 (1): 185–93. PMID 1351762. 
• Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724. 
• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. 
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome 31 (2): 745–56. PMID 2576652. 
• Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". J. Assist. Reprod. Genet. 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Bodey B, Bodey B, Siegel SE, Kaiser HE (2000). "Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment". In Vivo 14 (3): 419–24. PMID 10904875. 
• Giannola DM, Shlomchik WD, Jegathesan M, et al. (2000). "Hematopoietic Expression of Hoxb4 Is Regulated in Normal and Leukemic Stem Cells through Transcriptional Activation of the Hoxb4 Promoter by Upstream Stimulating Factor (Usf)-1 and Usf-2". J. Exp. Med. 192 (10): 1479–90. doi:10.1084/jem.192.10.1479. PMC 2193192. PMID 11085749. 
• Pan Q, Simpson RU (2001). "Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression". J. Endocrinol. 169 (1): 153–9. doi:10.1677/joe.0.1690153. PMID 11250656. 
• Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX Homeodomain Proteins Block CBP Histone Acetyltransferase Activity". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930. 
• Kömüves LG, Michael E, Arbeit JM, et al. (2002). "HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation". Dev. Dyn. 224 (1): 58–68. doi:10.1002/dvdy.10085. PMID 11984874. 
• Buske C, Feuring-Buske M, Abramovich C, et al. (2002). "Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells". Blood 100 (3): 862–8. doi:10.1182/blood-2002-01-0220. PMID 12130496. 
• Schiedlmeier B, Klump H, Will E, et al. (2003). "High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation". Blood 101 (5): 1759–68. doi:10.1182/blood-2002-03-0767. PMID 12406897. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Theokli C, Morsi El-Kadi AS, Morgan R (2004). "TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation". Dev. Dyn. 227 (1): 48–55. doi:10.1002/dvdy.10287. PMID 12701098. 
• Kömüves LG, Ma XK, Stelnicki E, et al. (2004). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development". Dev. Dyn. 227 (2): 192–202. doi:10.1002/dvdy.10290. PMID 12761847. 
• Zhu J, Giannola DM, Zhang Y, et al. (2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656. 

External links

• HOXB4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.