Microarrays Gateway

Gene expression during poxvirus infection

A microarray study in cells infected with cowpox, monkeypox or vaccinia virus showed differential expression of immune responses genes, providing a key resource for understanding these important zoonotic infections

In search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.

Genomic insights into Geospiza

204 years after Charles Darwin’s birth, sequencing of the genome of the Darwin’s Finch Geospiza magnirostris reveals over 13,000 predicted genes, of which two under positive selection may have contributed to beak morphology evolution, which so interested Darwin.

Chromatin influences transcription factories

Chromatin can act as a multi-block copolymer with active-inactive monomers that spontaneously self-organize to form microdomains, demonstrating that geometrical constraints alone can potentially yield an organized transcription factory.

Glycoproteins as tumor markers

As there has been limited success in the development of glycoprotein tumor markers, Eleftherios Diamandis and colleagues review the challenges, and discuss how new technology will facilitate quantification of these biomarkers for clinical use.