CLEC10A

 

C-type lectin domain family 10, member A
Identifiers
Symbols	CLEC10A; CD301; CLECSF13; CLECSF14; HML; HML2; MGL
External IDs	OMIM: 605999 MGI: 2385729 HomoloGene: 7836 GeneCards: CLEC10A Gene
Gene Ontology Molecular function • carbohydrate binding Cellular component • plasma membrane • integral to membrane Biological process • endocytosis • innate immune response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10462	17312
Ensembl	ENSG00000132514	ENSMUSG00000000318
UniProt	Q8IUN9	P49300
RefSeq (mRNA)	NM_006344.2	NM_001204252.1
RefSeq (protein)	NP_006335.2	NP_001191181.1
Location (UCSC)	Chr 17: 6.98 – 6.98 Mb	Chr 11: 70.16 – 70.17 Mb
PubMed search	[1]	[2]

C-type lectin domain family 10 member A also known as CLEC10A is a protein that in humans is encoded by the CLEC10A gene.

Function

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
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• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• van Vliet SJ, Steeghs L, Bruijns SC, et al. (2009). Seifert, H. Steven. ed. "Variation of Neisseria gonorrhoeae Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses". PLoS Pathog. 5 (10): e1000625. doi:10.1371/journal.ppat.1000625. PMC 2757725. PMID 19834553. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2757725. 
• Iijima M, Tomita M, Morozumi S, et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP". Neurology 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.