GABBR2

Gamma-aminobutyric acid (GABA) B receptor, 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4F11, 4F12
Identifiers
Symbols	GABBR2; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099
External IDs	OMIM: 607340 MGI: 2386030 HomoloGene: 55902 IUPHAR: GABAB2 ChEMBL: 5034 GeneCards: GABBR2 Gene
Gene Ontology Molecular function • G-protein coupled GABA receptor activity Cellular component • cytoplasm • plasma membrane • integral to plasma membrane • cell junction • neuron projection • postsynaptic membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • gamma-aminobutyric acid signaling pathway • synaptic transmission Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9568	242425
Ensembl	ENSG00000136928	ENSMUSG00000039809
UniProt	O75899	Q80T41
RefSeq (mRNA)	NM_005458.7	NM_001081141.1
RefSeq (protein)	NP_005449.5	NP_001074610.1
Location (UCSC)	Chr 9: 101.05 – 101.47 Mb	Chr 4: 46.66 – 46.99 Mb
PubMed search	[1]	[2]

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABA_B2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]

Interactions

GABBR2 has been shown to interact with GABBR1.

See also

• GABAB receptor

External links

• "GABA_B Receptors: GABA_B2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2933. 

Further reading

• White JH, Wise A, Main MJ et al. (1999). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature 396 (6712): 679–82. doi:10.1038/25354. PMID 9872316. 
• Ng GY, Clark J, Coulombe N et al. (1999). "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity". J. Biol. Chem. 274 (12): 7607–10. doi:10.1074/jbc.274.12.7607. PMID 10075644. 
• Ng GY, McDonald T, Bonnert T et al. (1999). "Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9". Genomics 56 (3): 288–95. doi:10.1006/geno.1998.5706. PMID 10087195. 
• Martin SC, Russek SJ, Farb DH (1999). "Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1". Mol. Cell. Neurosci. 13 (3): 180–91. doi:10.1006/mcne.1999.0741. PMID 10328880. 
• Clark JA, Mezey E, Lam AS, Bonner TI (2000). "Distribution of the GABA(B) receptor subunit gb2 in rat CNS". Brain Res. 860 (1–2): 41–52. doi:10.1016/S0006-8993(00)01958-2. PMID 10727622. 
• Sullivan R, Chateauneuf A, Coulombe N et al. (2000). "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor". J. Pharmacol. Exp. Ther. 293 (2): 460–7. PMID 10773016. 
• White JH, McIllhinney RA, Wise A et al. (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. doi:10.1073/pnas.240452197. PMC 17684. PMID 11087824. //www.ncbi.nlm.nih.gov/pmc/articles/PMC17684/. 
• Kitano J, Kimura K, Yamazaki Y et al. (2002). "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4): 1280–9. PMID 11850456. 
• Salim K, Fenton T, Bacha J et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Furtinger S, Pirker S, Czech T et al. (2004). "Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy". Neurosci. Lett. 352 (2): 141–5. doi:10.1016/j.neulet.2003.08.046. PMID 14625043. 
• Waldvogel HJ, Billinton A, White JH et al. (2004). "Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits". J. Comp. Neurol. 470 (4): 339–56. doi:10.1002/cne.20005. PMID 14961561. 
• Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004). "Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking". J. Biol. Chem. 279 (18): 18840–50. doi:10.1074/jbc.M313470200. PMID 14966130. 
• Uezono Y, Kaibara M, Hayashi H et al. (2004). "Characterization of GABAB receptor in the human colon". J. Pharmacol. Sci. 94 (2): 211–3. doi:10.1254/jphs.94.211. PMID 14978362. 
• Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2734081/. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/. 
• Hlavackova V, Goudet C, Kniazeff J et al. (2005). "Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR". EMBO J. 24 (3): 499–509. doi:10.1038/sj.emboj.7600557. PMC 548662. PMID 15660124. //www.ncbi.nlm.nih.gov/pmc/articles/PMC548662/. 
• DeGiorgis JA, Jaffe H, Moreira JE et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Osawa Y, Xu D, Sternberg D et al. (2006). "Functional expression of the GABAB receptor in human airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (5): L923–31. doi:10.1152/ajplung.00185.2006. PMID 16829628. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.