FZD6

Frizzled family receptor 6
Identifiers
Symbols	FZD6; FZ-6; FZ6; HFZ6; NDNC10
External IDs	OMIM: 603409 MGI: 108474 HomoloGene: 2617 IUPHAR: FZD6 GeneCards: FZD6 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • protein binding • Wnt-protein binding • PDZ domain binding • ubiquitin protein ligase binding • Wnt-activated receptor activity Cellular component • cytoplasm • plasma membrane • integral to plasma membrane • apicolateral plasma membrane • neuron projection membrane • apical part of cell Biological process • angiogenesis • establishment of planar polarity • neural tube closure • hair follicle development • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • axonogenesis • gonad development • platelet activation • cell proliferation in midbrain • non-canonical Wnt receptor signaling pathway • inner ear morphogenesis • negative regulation of sequence-specific DNA binding transcription factor activity • Wnt receptor signaling pathway, planar cell polarity pathway • negative regulation of canonical Wnt receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8323	14368
Ensembl	ENSG00000164930	ENSMUSG00000022297
UniProt	O60353	Q61089
RefSeq (mRNA)	NM_001164615.1	NM_001162494.1
RefSeq (protein)	NP_001158087.1	NP_001155966.1
Location (UCSC)	Chr 8: 104.31 – 104.35 Mb	Chr 15: 39.01 – 39.04 Mb
PubMed search	[1]	[2]

Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.The FZD6 protein is believed to be the receptor for the WNT4 ligand.

Interactions

FZD6 has been shown to interact with Secreted frizzled-related protein 1.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₆". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3064.

Further reading

• Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. //www.ncbi.nlm.nih.gov/pmc/articles/PMC21233/.
• Bafico A, Gazit A, Pramila T, et al. (1999). "Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.". J. Biol. Chem. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129/.
• Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.