GPR15

G protein-coupled receptor 15
Identifiers
Symbols	GPR15; MGC126828; MGC126830
External IDs	OMIM: 601166 MGI: 1918473 HomoloGene: 3869 IUPHAR: GPR15 GeneCards: GPR15 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • G-protein coupled purinergic nucleotide receptor activity Cellular component • integral to plasma membrane Biological process • G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2838	71223
Ensembl	ENSG00000154165	ENSMUSG00000047293
UniProt	P49685	Q0VDU3
RefSeq (mRNA)	NM_005290.1	NM_001162955.1
RefSeq (protein)	NP_005281.1	NP_001156427.1
Location (UCSC)	Chr 3: 98.25 – 98.25 Mb	Chr 16: 58.72 – 58.72 Mb
PubMed search	[1]	[2]

G-protein coupled receptor 15 is a protein that in humans is encoded by the GPR15 gene.

Further reading

• Cunningham AL, Li S, Juarez J et al. (2000). "The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes". J. Leukoc. Biol. 68 (3): 311–7. PMID 10985245.
• Deng HK, Unutmaz D, KewalRamani VN, Littman DR (1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature 388 (6639): 296–300. doi:10.1038/40894. PMID 9230441.
• Farzan M, Choe H, Martin K et al. (1997). "Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection". J. Exp. Med. 186 (3): 405–11. doi:10.1084/jem.186.3.405. PMC 2198994. PMID 9236192. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2198994/.
• Clayton F, Kotler DP, Kuwada SK et al. (2001). "Gp120-Induced Bob/GPR15 Activation : A Possible Cause of Human Immunodeficiency Virus Enteropathy". Am. J. Pathol. 159 (5): 1933–9. doi:10.1016/S0002-9440(10)63040-4. PMC 1867054. PMID 11696454. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1867054/.
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Croitoru-Lamoury J, Guillemin GJ, Boussin FD et al. (2003). "Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation". Glia 41 (4): 354–70. doi:10.1002/glia.10181. PMID 12555203.
• Maresca M, Mahfoud R, Garmy N et al. (2003). "The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line". J. Biomed. Sci. 10 (1): 156–66. doi:10.1159/000068089. PMID 12566994.
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Blaak H, Boers PH, Gruters RA et al. (2005). "CCR5, GPR15, and CXCR6 Are Major Coreceptors of Human Immunodeficiency Virus Type 2 Variants Isolated from Individuals with and without Plasma Viremia". J. Virol. 79 (3): 1686–700. doi:10.1128/JVI.79.3.1686-1700.2005. PMC 544080. PMID 15650194. //www.ncbi.nlm.nih.gov/pmc/articles/PMC544080/.
• Cilliers T, Willey S, Sullivan WM et al. (2005). "Use of alternate coreceptors on primary cells by two HIV-1 isolates". Virology 339 (1): 136–44. doi:10.1016/j.virol.2005.05.027. PMID 15992849.