FZD1

Frizzled family receptor 1
Identifiers
Symbols	FZD1; DKFZp564G072; FLJ95923
External IDs	OMIM: 603408 MGI: 1196625 HomoloGene: 20750 IUPHAR: FZD1 GeneCards: FZD1 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • receptor binding • protein binding • Wnt-protein binding • PDZ domain binding • protein homodimerization activity • Wnt-activated receptor activity • protein heterodimerization activity Cellular component • cytoplasm • cell surface • integral to membrane • neuron projection membrane • apical part of cell Biological process • positive regulation of protein phosphorylation • vasculature development • membranous septum morphogenesis • muscular septum morphogenesis • outflow tract morphogenesis • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • axonogenesis • brain development • gonad development • embryo development • neuron differentiation • negative regulation of BMP signaling pathway • epithelial cell differentiation • negative regulation of catenin import into nucleus • autocrine signaling • response to drug • canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation • canonical Wnt receptor signaling pathway involved in osteoblast differentiation • regulation of osteoblast differentiation • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • lung alveolus development • positive regulation of sequence-specific DNA binding transcription factor activity • hard palate development • canonical Wnt receptor signaling pathway • cellular response to vitamin D • cellular response to growth factor stimulus • cellular response to peptide hormone stimulus • negative regulation of canonical Wnt receptor signaling pathway • planar cell polarity pathway involved in neural tube closure Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8321	14362
Ensembl	ENSG00000157240	ENSMUSG00000044674
UniProt	Q9UP38	O70421
RefSeq (mRNA)	NM_003505.1	NM_021457.3
RefSeq (protein)	NP_003496.1	NP_067432.2
Location (UCSC)	Chr 7: 90.89 – 90.9 Mb	Chr 5: 4.75 – 4.76 Mb
PubMed search	[1]	[2]

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3059. 

Further reading

• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. //www.ncbi.nlm.nih.gov/pmc/articles/PMC21479/. 
• Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.". Oncogene 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084. 
• DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (2002). "The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor.". Naunyn Schmiedebergs Arch. Pharmacol. 365 (5): 341–8. doi:10.1007/s00210-002-0540-3. PMID 12012019. 
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2882961/. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Zilberberg A, Yaniv A, Gazit A (2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". J. Biol. Chem. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301. 
• Wu J, Klein TJ, Mlodzik M (2006). "Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity". PLoS Biol. 2 (7): E158. doi:10.1371/journal.pbio.0020158. PMC 449784. PMID 15252441. //www.ncbi.nlm.nih.gov/pmc/articles/PMC449784/. 
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/. 
• Yang L, Yamasaki K, Shirakata Y, et al. (2006). "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". J. Dermatol. Sci. 42 (2): 111–9. doi:10.1016/j.jdermsci.2005.12.011. PMID 16442268. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.