GPR34

G protein-coupled receptor 34
Identifiers
Symbol	GPR34
External IDs	OMIM: 300241 MGI: 1346334 HomoloGene: 36174 IUPHAR: GPR34 GeneCards: GPR34 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • protein C-terminus binding • PDZ domain binding • protein complex binding • G-protein coupled purinergic nucleotide receptor activity Cellular component • cytoplasm • integral to plasma membrane • dendrite • protein complex Biological process • intracellular protein transport • G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2857	23890
Ensembl	ENSG00000171659	ENSMUSG00000040229
UniProt	Q9UPC5	Q9R1K6
RefSeq (mRNA)	NM_001033513.2	NM_011823.4
RefSeq (protein)	NP_001091048.1	NP_035953.3
Location (UCSC)	Chr X: 41.55 – 41.56 Mb	Chr X: 13.63 – 13.64 Mb
PubMed search	[1]	[2]

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]

Further reading

• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549. 
• Jacobi FK, Broghammer M, Pesch K, et al. (2000). "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Hum. Genet. 107 (1): 89–91. doi:10.1007/s004390050017. PMID 10982042. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/. 
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
• Engemaier E, Römpler H, Schöneberg T, Schulz A (2006). "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34". Genomics 87 (2): 254–64. doi:10.1016/j.ygeno.2005.10.001. PMID 16338117. 
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
• Liebscher I, Müller U, Teupser D, et al. (2011). "Altered immune response in mice deficient for the G protein-coupled receptor GPR34". J Biol Chem. 286 (3): 2101-10. doi:10.1074/jbc.M110.196659. PMC 3023507. PMID 21097509. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3023507/. 
• Ritscher L, Engemaier E, Stäubert C, et al. (2012). "The ligand specificity of the G-protein-coupled receptor GPR34". Biochem J. 443 (3): 841-50. doi:10.1042/BJ20112090. PMID 22348703.