TAS2R3

Taste receptor, type 2, member 3
Identifiers
Symbols	TAS2R3; T2R3
External IDs	OMIM: 604868 MGI: 3606604 HomoloGene: 23231 IUPHAR: TAS2R3 GeneCards: TAS2R3 Gene
Gene Ontology Molecular function • taste receptor activity Cellular component • integral to membrane Biological process • signal transduction • sensory perception of taste • detection of chemical stimulus involved in sensory perception of taste Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50831	574417
Ensembl	ENSG00000127362	ENSMUSG00000052850
UniProt	Q9NYW6	Q7TQA7
RefSeq (mRNA)	NM_016943.2	NM_001025385.1
RefSeq (protein)	NP_058639.1	NP_001020556.1
Location (UCSC)	Chr 7: 141.46 – 141.46 Mb	Chr 6: 40.49 – 40.49 Mb
PubMed search	[1]	[2]

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.

See also

• Taste receptor

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
• Adler E, Hoon MA, Mueller KL et al. (2000). "A novel family of mammalian taste receptors". Cell 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
• Chandrashekar J, Mueller KL, Hoon MA et al. (2000). "T2Rs function as bitter taste receptors". Cell 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
• Firestein S (2000). "The good taste of genomics". Nature 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221.
• Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
• Ueda T, Ugawa S, Ishida Y et al. (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun. 285 (1): 147–51. doi:10.1006/bbrc.2001.5136. PMID 11437385.
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Zhang Y, Hoon MA, Chandrashekar J et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
• Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2882961/.
• Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1449719/.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.